Tyzzer's Disease

Karina C. Fresneda, Francisco R Carvallo chaigneau

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Tyzzer's disease is an infectious disease caused by Clostridium piliforme. The most susceptible species are horses, rabbits, and laboratory animals. This chapter discusses etiology, epidemiology, pathogenesis, clinical signs, clinico-pathologic findings, diagnosis, treatment, prevention and control for Tyzzer's disease. A presumptive diagnosis of Tyzzer's disease can be reached based on gross observations. A definitive diagnosis, however, should be based upon the histologic demonstration of hepatic, intestinal, and/or myocardial lesions and the presence of bacteria in the cytoplasm of affected cells. As with the clinical signs and gross lesions, microscopic changes are similar in all the species. Due to the impossibility of cultivating C. piliforme in vitro using conventional cultural methods, antimicrobial susceptibility patterns were determined in embryonated eggs. Penicillin, tetracycline, erythromycin, and streptomycin were effective against this microorganism. Good hygiene may be beneficial for decreasing the likelihood that disease will occur.

Original languageEnglish (US)
Title of host publicationClostridial Diseases in Animals
Number of pages11
ISBN (Electronic)9781118728291
ISBN (Print)9781118728406
StatePublished - Apr 8 2016


  • Adult horses
  • C. piliforme
  • Erythromycin
  • Penicillin
  • Streptomycin
  • Tetracycline
  • Tyzzer's disease

ASJC Scopus subject areas

  • veterinary(all)


Dive into the research topics of 'Tyzzer's Disease'. Together they form a unique fingerprint.

Cite this