Tyrosine hydroxylase and galanin mRNA levels in locus coeruleus neurons are increased following reserpine administration

M. C. Austin, S. L. Cottingham, S. M. Paul, Jacqueline Crawley

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The neuropeptide galanin coexists in 80-90% of the norepinephrine-containing neurons in the locus coeruleus. In situ hybridization histochemistry was used to examine the effects of reserpine treatment or swim stress on tyrosine hydroxylase and galanin mRNA concentrations in locus coeruleus neurons. Reserpine administration significantly increased tyrosine hydroxylase and galanin mRNA levels in the locus coeruleus. The reserpine-induced increase in tyrosine hydroxylase mRNA was significantly correlated with the reserpine-induced increase in galanin mRNA. Three consecutive days of swim stress did not significantly alter either tyrosine hydroxylase or galanin mRNA concentrations in the locus coeruleus. These data suggest that both tyrosine hydroxylase and galanin gene expression in locus coeruleus neurons may be regulated by a reserpine-sensitive mechanism.

Original languageEnglish (US)
Pages (from-to)351-357
Number of pages7
JournalSynapse
Volume6
Issue number4
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Pharmacology

Fingerprint Dive into the research topics of 'Tyrosine hydroxylase and galanin mRNA levels in locus coeruleus neurons are increased following reserpine administration'. Together they form a unique fingerprint.

  • Cite this