Type i NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma

Gourapura J. Renukaradhya, Masood A. Khan, Marcus Vieira, Wenjun Du, Jacquelyn Gervay-Hague, Randy R. Brutkiewicz

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Natural killer T (NKT) cells are a T-cell subpopulation known to possess immu-noregulatory functions and recognize CD1d molecules. The majority of NKT cells express an invariant T-cell receptor (TCR) α chain rearrangement (Vα14Jα18 in mice; Vα24Jα18 in humans) and are called type I NKT cells; all other NKT cells are type II. In the current study, we have analyzed the roles for these NKT-cell subsets in the host's innate antitumor response against a murine B-cell lym-phoma model in vivo. In tumor-bearing mice, we found that type I NKT cells conferred protection in a CD1d- dependent manner, whereas type II NKT cells exhibited inhibitory activity. Pro- and anti-inflammatory cytokines secreted by splenocytes from tumor-bearing mice correlated with tumor progression. Myeloid cells (CD11b +Gr1 +) were present in large numbers at the tumor site and in the spleen of tumor-bearing type I NKT-deficient mice, suggesting that antitumor immunosurveillance was inhibited by CD11b +Gr1 + cells. Overall, these data suggest that there are distinct roles for NKT-cell subsets in response to a B-cell lymphoma in vivo, pointing to potential novel targets to be exploited in immuno-therapeutic approaches against blood cancers.

Original languageEnglish (US)
Pages (from-to)5637-5645
Number of pages9
JournalBlood
Volume111
Issue number12
DOIs
StatePublished - Jun 15 2008

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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