Abstract
Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4343-4351 |
| Number of pages | 9 |
| Journal | Journal of Immunology |
| Volume | 176 |
| Issue number | 7 |
| State | Published - Apr 1 2006 |
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ASJC Scopus subject areas
- Immunology
Cite this
Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection. / Coro, Elizabeth S.; Chang, W. L William; Baumgarth, Nicole.
In: Journal of Immunology, Vol. 176, No. 7, 01.04.2006, p. 4343-4351.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection
AU - Coro, Elizabeth S.
AU - Chang, W. L William
AU - Baumgarth, Nicole
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.
AB - Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.
UR - http://www.scopus.com/inward/record.url?scp=33646027625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646027625&partnerID=8YFLogxK
M3 - Article
C2 - 16547272
AN - SCOPUS:33646027625
VL - 176
SP - 4343
EP - 4351
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -