Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection

Elizabeth S. Coro, W. L William Chang, Nicole Baumgarth

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.

Original languageEnglish (US)
Pages (from-to)4343-4351
Number of pages9
JournalJournal of Immunology
Volume176
Issue number7
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Immunology

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