Type C botulism in turkeys: determination of the median toxic dose.

J. S. Jeffrey, F. D. Galey, C. U. Meteyer, H. Kinde, M. Rezvani

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (MLD/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior paresis, or no effect, depending upon the dose. The TD50 causing posterior paresis was calculated as 25.75 MLD/kg (confidence interval = 17.08-38.82 MLD/kg). Posterior paresis was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior paresis was similar to the clinical syndrome observed in an unsolved field investigation.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Issue number1
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)


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