Type C botulism in turkeys: determination of the median toxic dose.

J. S. Jeffrey, F. D. Galey, C. U. Meteyer, H. Kinde, Hailu Kinde

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (MLD/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior paresis, or no effect, depending upon the dose. The TD50 causing posterior paresis was calculated as 25.75 MLD/kg (confidence interval = 17.08-38.82 MLD/kg). Posterior paresis was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior paresis was similar to the clinical syndrome observed in an unsolved field investigation.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Volume6
Issue number1
StatePublished - Jan 1994

Fingerprint

Botulism
botulism
paresis
Poisons
Paresis
dosage
toxins
lethal dose
Birds
poisoning
confidence interval
Body Weight
Confidence Intervals
death
body weight
birds
mice
testing

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Type C botulism in turkeys : determination of the median toxic dose. / Jeffrey, J. S.; Galey, F. D.; Meteyer, C. U.; Kinde, H.; Kinde, Hailu.

In: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, Vol. 6, No. 1, 01.1994, p. 93-95.

Research output: Contribution to journalArticle

@article{d7ab8da9ad9f4188b7a7211ec28ca131,
title = "Type C botulism in turkeys: determination of the median toxic dose.",
abstract = "The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (MLD/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior paresis, or no effect, depending upon the dose. The TD50 causing posterior paresis was calculated as 25.75 MLD/kg (confidence interval = 17.08-38.82 MLD/kg). Posterior paresis was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior paresis was similar to the clinical syndrome observed in an unsolved field investigation.",
author = "Jeffrey, {J. S.} and Galey, {F. D.} and Meteyer, {C. U.} and H. Kinde and Hailu Kinde",
year = "1994",
month = "1",
language = "English (US)",
volume = "6",
pages = "93--95",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "1",

}

TY - JOUR

T1 - Type C botulism in turkeys

T2 - determination of the median toxic dose.

AU - Jeffrey, J. S.

AU - Galey, F. D.

AU - Meteyer, C. U.

AU - Kinde, H.

AU - Kinde, Hailu

PY - 1994/1

Y1 - 1994/1

N2 - The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (MLD/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior paresis, or no effect, depending upon the dose. The TD50 causing posterior paresis was calculated as 25.75 MLD/kg (confidence interval = 17.08-38.82 MLD/kg). Posterior paresis was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior paresis was similar to the clinical syndrome observed in an unsolved field investigation.

AB - The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (MLD/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior paresis, or no effect, depending upon the dose. The TD50 causing posterior paresis was calculated as 25.75 MLD/kg (confidence interval = 17.08-38.82 MLD/kg). Posterior paresis was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior paresis was similar to the clinical syndrome observed in an unsolved field investigation.

UR - http://www.scopus.com/inward/record.url?scp=0028186540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028186540&partnerID=8YFLogxK

M3 - Article

C2 - 8011788

AN - SCOPUS:0028186540

VL - 6

SP - 93

EP - 95

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 1

ER -