Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative

J. Neumann, F. C. Hofmann, U. Heilmeier, W. Ashmeik, K. Tang, A. S. Gersing, B. J. Schwaiger, M. C. Nevitt, G. B. Joseph, Nancy E Lane, C. E. McCulloch, T. M. Link

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Purpose: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. Methods: From the Osteoarthritis Initiative (OAI) cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren–Lawrence score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice multi-echo spin-echo sequences. Texture of cartilage T2 maps was obtained via grey level co-occurrence matrix analysis. Linear regression analysis was used to compare cross-sectional and changes in T2 and texture parameters between the groups. Results: Both study groups were similar in age (63.3 vs 63.0 years, P = 0.70), BMI (30.9 vs 31.2 kg/m2, P = 0.52), sex (female 53.6% vs 54.1%, P = 0.92) and KL score distribution (P = 0.97). In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls. Global T2 values increased almost twice as much; 1.77ms vs 0.98ms (0.79ms [CI: 0.39,1.19]) (P < 0.001). Additionally, global T2 values showed a significantly higher increase in the bone layer (P = 0.006), and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values (P < 0.05), indicating a more disordered cartilage composition. Conclusion: Cartilage T2 values in diabetics show a faster increase with a consistently more heterogeneous cartilage texture composition. DM seems to be a risk factor for developing early OA with an accelerated degeneration of the articular cartilage in the knee.

Original languageEnglish (US)
Pages (from-to)751-761
Number of pages11
JournalOsteoarthritis and Cartilage
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2018

Keywords

  • Biomarkers
  • Cartilage imaging
  • Diabetes mellitus
  • Knee osteoarthritis
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

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    Neumann, J., Hofmann, F. C., Heilmeier, U., Ashmeik, W., Tang, K., Gersing, A. S., Schwaiger, B. J., Nevitt, M. C., Joseph, G. B., Lane, N. E., McCulloch, C. E., & Link, T. M. (2018). Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative. Osteoarthritis and Cartilage, 26(6), 751-761. https://doi.org/10.1016/j.joca.2018.03.010