Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative

J. Neumann, F. C. Hofmann, U. Heilmeier, W. Ashmeik, K. Tang, A. S. Gersing, B. J. Schwaiger, M. C. Nevitt, G. B. Joseph, Nancy E Lane, C. E. McCulloch, T. M. Link

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. Methods: From the Osteoarthritis Initiative (OAI) cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren–Lawrence score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice multi-echo spin-echo sequences. Texture of cartilage T2 maps was obtained via grey level co-occurrence matrix analysis. Linear regression analysis was used to compare cross-sectional and changes in T2 and texture parameters between the groups. Results: Both study groups were similar in age (63.3 vs 63.0 years, P = 0.70), BMI (30.9 vs 31.2 kg/m2, P = 0.52), sex (female 53.6% vs 54.1%, P = 0.92) and KL score distribution (P = 0.97). In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls. Global T2 values increased almost twice as much; 1.77ms vs 0.98ms (0.79ms [CI: 0.39,1.19]) (P < 0.001). Additionally, global T2 values showed a significantly higher increase in the bone layer (P = 0.006), and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values (P < 0.05), indicating a more disordered cartilage composition. Conclusion: Cartilage T2 values in diabetics show a faster increase with a consistently more heterogeneous cartilage texture composition. DM seems to be a risk factor for developing early OA with an accelerated degeneration of the articular cartilage in the knee.

Original languageEnglish (US)
Pages (from-to)751-761
Number of pages11
JournalOsteoarthritis and Cartilage
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

Cartilage
Medical problems
Osteoarthritis
Type 2 Diabetes Mellitus
Textures
Diabetes Mellitus
Knee
Patella
Articular Cartilage
Time measurement
Chemical analysis
Linear Models
Linear regression
Regression analysis
Relaxation time
Deterioration
Regression Analysis
Bone
Bone and Bones

Keywords

  • Biomarkers
  • Cartilage imaging
  • Diabetes mellitus
  • Knee osteoarthritis
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

Cite this

Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls : data from the Osteoarthritis Initiative. / Neumann, J.; Hofmann, F. C.; Heilmeier, U.; Ashmeik, W.; Tang, K.; Gersing, A. S.; Schwaiger, B. J.; Nevitt, M. C.; Joseph, G. B.; Lane, Nancy E; McCulloch, C. E.; Link, T. M.

In: Osteoarthritis and Cartilage, Vol. 26, No. 6, 01.06.2018, p. 751-761.

Research output: Contribution to journalArticle

Neumann, J, Hofmann, FC, Heilmeier, U, Ashmeik, W, Tang, K, Gersing, AS, Schwaiger, BJ, Nevitt, MC, Joseph, GB, Lane, NE, McCulloch, CE & Link, TM 2018, 'Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative', Osteoarthritis and Cartilage, vol. 26, no. 6, pp. 751-761. https://doi.org/10.1016/j.joca.2018.03.010
Neumann, J. ; Hofmann, F. C. ; Heilmeier, U. ; Ashmeik, W. ; Tang, K. ; Gersing, A. S. ; Schwaiger, B. J. ; Nevitt, M. C. ; Joseph, G. B. ; Lane, Nancy E ; McCulloch, C. E. ; Link, T. M. / Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls : data from the Osteoarthritis Initiative. In: Osteoarthritis and Cartilage. 2018 ; Vol. 26, No. 6. pp. 751-761.
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abstract = "Purpose: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. Methods: From the Osteoarthritis Initiative (OAI) cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren–Lawrence score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice multi-echo spin-echo sequences. Texture of cartilage T2 maps was obtained via grey level co-occurrence matrix analysis. Linear regression analysis was used to compare cross-sectional and changes in T2 and texture parameters between the groups. Results: Both study groups were similar in age (63.3 vs 63.0 years, P = 0.70), BMI (30.9 vs 31.2 kg/m2, P = 0.52), sex (female 53.6{\%} vs 54.1{\%}, P = 0.92) and KL score distribution (P = 0.97). In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls. Global T2 values increased almost twice as much; 1.77ms vs 0.98ms (0.79ms [CI: 0.39,1.19]) (P < 0.001). Additionally, global T2 values showed a significantly higher increase in the bone layer (P = 0.006), and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values (P < 0.05), indicating a more disordered cartilage composition. Conclusion: Cartilage T2 values in diabetics show a faster increase with a consistently more heterogeneous cartilage texture composition. DM seems to be a risk factor for developing early OA with an accelerated degeneration of the articular cartilage in the knee.",
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T1 - Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls

T2 - data from the Osteoarthritis Initiative

AU - Neumann, J.

AU - Hofmann, F. C.

AU - Heilmeier, U.

AU - Ashmeik, W.

AU - Tang, K.

AU - Gersing, A. S.

AU - Schwaiger, B. J.

AU - Nevitt, M. C.

AU - Joseph, G. B.

AU - Lane, Nancy E

AU - McCulloch, C. E.

AU - Link, T. M.

PY - 2018/6/1

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N2 - Purpose: Osteoarthritis (OA) and diabetes mellitus (DM) share common risk factors with a potential underlying relationship between both diseases. The purpose of this study was to investigate the longitudinal effects of DM on cartilage deterioration over 24-months with MR-based T2 relaxation time measurements. Methods: From the Osteoarthritis Initiative (OAI) cohort 196 diabetics were matched in small sets for age, sex, BMI and Kellgren–Lawrence score with 196 non-diabetic controls. Knee cartilage semi-automatic segmentation was performed on 2D multi-slice multi-echo spin-echo sequences. Texture of cartilage T2 maps was obtained via grey level co-occurrence matrix analysis. Linear regression analysis was used to compare cross-sectional and changes in T2 and texture parameters between the groups. Results: Both study groups were similar in age (63.3 vs 63.0 years, P = 0.70), BMI (30.9 vs 31.2 kg/m2, P = 0.52), sex (female 53.6% vs 54.1%, P = 0.92) and KL score distribution (P = 0.97). In diabetics, except for the patella, all compartments showed a significantly higher increase in mean T2 values when compared to non-diabetic controls. Global T2 values increased almost twice as much; 1.77ms vs 0.98ms (0.79ms [CI: 0.39,1.19]) (P < 0.001). Additionally, global T2 values showed a significantly higher increase in the bone layer (P = 0.006), and in a separate analysis of the texture parameters, diabetics also showed consistently higher texture values (P < 0.05), indicating a more disordered cartilage composition. Conclusion: Cartilage T2 values in diabetics show a faster increase with a consistently more heterogeneous cartilage texture composition. DM seems to be a risk factor for developing early OA with an accelerated degeneration of the articular cartilage in the knee.

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