Two-year prospective study of major depressive disorder in HIV-infected men

J. Hampton Atkinson, Robert K. Heaton, Thomas L. Patterson, Tanya Wolfson, Reena Deutsch, Stephen J. Brown, J. Summers, Andres F Sciolla, R. Gutierrez, Ronald J. Ellis, Ian Abramson, John R. Hesselink, J. Allen McCutchan, Igor Grant

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Abstract

Objective: The risks and factors contributing to major depressive episodes in HIV infection remain unclear. This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N = 297) and uninfected (HIV-) risk-group controls (N = 90). Methods: By design participants at entry were without current major depression, substance dependence or major anxiety disorder. Standardized neuromedical, neuropsychological, neuroimaging, life events, and psychiatric assessments (Structured Clinical Interview for DSM III-R) were conducted semi-annually for those with AIDS, and annually for all others. Results: Lifetime prevalence of major depression or other psychiatric disorder did not differ at baseline between HIV+ men and controls. On a two-year follow-up those with symptomatic HIV disease were significantly more likely to experience a major depressive episode than were asymptomatic HIV+ individuals and HIV-controls (p < 0.05). Episodes were as likely to be first onset as recurrent depression. After baseline disease stage and medical variables associated with HIV infection were controlled, a lifetime history of major depression, or of lifetime psychiatric comorbidity (two or more psychiatric disorders), predicted subsequent major depressive episode (p < 0.05). Neither HIV disease progression during follow-up, nor the baseline presence of neurocognitive impairment, clinical brain imaging abnormality, or marked life adversity predicted a later major depressive episode. Limitations: Research cohort of men examined before era of widespread use of advanced anti-HIV therapies. Conclusions: Symptomatic HIV disease, but not HIV infection itself, increases intermediate-term risk of major depression. Prior psychiatric history most strongly predicted future vulnerability.

Original languageEnglish (US)
Pages (from-to)225-234
Number of pages10
JournalJournal of Affective Disorders
Volume108
Issue number3
DOIs
StatePublished - Jun 2008

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Major Depressive Disorder
HIV
Prospective Studies
Psychiatry
Depression
HIV Infections
Neuroimaging
Anxiety Disorders
Diagnostic and Statistical Manual of Mental Disorders
Substance-Related Disorders
Disease Progression
Comorbidity
Acquired Immunodeficiency Syndrome
Interviews
Control Groups

Keywords

  • AIDS
  • Human immunodeficiency virus
  • Major depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Atkinson, J. H., Heaton, R. K., Patterson, T. L., Wolfson, T., Deutsch, R., Brown, S. J., ... Grant, I. (2008). Two-year prospective study of major depressive disorder in HIV-infected men. Journal of Affective Disorders, 108(3), 225-234. https://doi.org/10.1016/j.jad.2007.10.017

Two-year prospective study of major depressive disorder in HIV-infected men. / Atkinson, J. Hampton; Heaton, Robert K.; Patterson, Thomas L.; Wolfson, Tanya; Deutsch, Reena; Brown, Stephen J.; Summers, J.; Sciolla, Andres F; Gutierrez, R.; Ellis, Ronald J.; Abramson, Ian; Hesselink, John R.; McCutchan, J. Allen; Grant, Igor.

In: Journal of Affective Disorders, Vol. 108, No. 3, 06.2008, p. 225-234.

Research output: Contribution to journalArticle

Atkinson, JH, Heaton, RK, Patterson, TL, Wolfson, T, Deutsch, R, Brown, SJ, Summers, J, Sciolla, AF, Gutierrez, R, Ellis, RJ, Abramson, I, Hesselink, JR, McCutchan, JA & Grant, I 2008, 'Two-year prospective study of major depressive disorder in HIV-infected men', Journal of Affective Disorders, vol. 108, no. 3, pp. 225-234. https://doi.org/10.1016/j.jad.2007.10.017
Atkinson JH, Heaton RK, Patterson TL, Wolfson T, Deutsch R, Brown SJ et al. Two-year prospective study of major depressive disorder in HIV-infected men. Journal of Affective Disorders. 2008 Jun;108(3):225-234. https://doi.org/10.1016/j.jad.2007.10.017
Atkinson, J. Hampton ; Heaton, Robert K. ; Patterson, Thomas L. ; Wolfson, Tanya ; Deutsch, Reena ; Brown, Stephen J. ; Summers, J. ; Sciolla, Andres F ; Gutierrez, R. ; Ellis, Ronald J. ; Abramson, Ian ; Hesselink, John R. ; McCutchan, J. Allen ; Grant, Igor. / Two-year prospective study of major depressive disorder in HIV-infected men. In: Journal of Affective Disorders. 2008 ; Vol. 108, No. 3. pp. 225-234.
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abstract = "Objective: The risks and factors contributing to major depressive episodes in HIV infection remain unclear. This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N = 297) and uninfected (HIV-) risk-group controls (N = 90). Methods: By design participants at entry were without current major depression, substance dependence or major anxiety disorder. Standardized neuromedical, neuropsychological, neuroimaging, life events, and psychiatric assessments (Structured Clinical Interview for DSM III-R) were conducted semi-annually for those with AIDS, and annually for all others. Results: Lifetime prevalence of major depression or other psychiatric disorder did not differ at baseline between HIV+ men and controls. On a two-year follow-up those with symptomatic HIV disease were significantly more likely to experience a major depressive episode than were asymptomatic HIV+ individuals and HIV-controls (p < 0.05). Episodes were as likely to be first onset as recurrent depression. After baseline disease stage and medical variables associated with HIV infection were controlled, a lifetime history of major depression, or of lifetime psychiatric comorbidity (two or more psychiatric disorders), predicted subsequent major depressive episode (p < 0.05). Neither HIV disease progression during follow-up, nor the baseline presence of neurocognitive impairment, clinical brain imaging abnormality, or marked life adversity predicted a later major depressive episode. Limitations: Research cohort of men examined before era of widespread use of advanced anti-HIV therapies. Conclusions: Symptomatic HIV disease, but not HIV infection itself, increases intermediate-term risk of major depression. Prior psychiatric history most strongly predicted future vulnerability.",
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AU - Summers, J.

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N2 - Objective: The risks and factors contributing to major depressive episodes in HIV infection remain unclear. This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N = 297) and uninfected (HIV-) risk-group controls (N = 90). Methods: By design participants at entry were without current major depression, substance dependence or major anxiety disorder. Standardized neuromedical, neuropsychological, neuroimaging, life events, and psychiatric assessments (Structured Clinical Interview for DSM III-R) were conducted semi-annually for those with AIDS, and annually for all others. Results: Lifetime prevalence of major depression or other psychiatric disorder did not differ at baseline between HIV+ men and controls. On a two-year follow-up those with symptomatic HIV disease were significantly more likely to experience a major depressive episode than were asymptomatic HIV+ individuals and HIV-controls (p < 0.05). Episodes were as likely to be first onset as recurrent depression. After baseline disease stage and medical variables associated with HIV infection were controlled, a lifetime history of major depression, or of lifetime psychiatric comorbidity (two or more psychiatric disorders), predicted subsequent major depressive episode (p < 0.05). Neither HIV disease progression during follow-up, nor the baseline presence of neurocognitive impairment, clinical brain imaging abnormality, or marked life adversity predicted a later major depressive episode. Limitations: Research cohort of men examined before era of widespread use of advanced anti-HIV therapies. Conclusions: Symptomatic HIV disease, but not HIV infection itself, increases intermediate-term risk of major depression. Prior psychiatric history most strongly predicted future vulnerability.

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