Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging

Zhongling Wang, Xiangdong Xue, Hongwei Lu, Yixuan He, Ziwei Lu, Zhijie Chen, Ye Yuan, Na Tang, Courtney A. Dreyer, Lizabeth Quigley, Nicholas Curro, Kit S. Lam, Jeffrey H. Walton, Tzu yin Lin, Angelique Y Louie, Dustin A. Gilbert, Kai Liu, Katherine W Ferrara, Yuanpei Li

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Distance-dependent magnetic resonance tuning (MRET) technology enables the sensing and quantitative imaging of biological targets in vivo, with the advantage of deep tissue penetration and fewer interactions with the surroundings as compared with those of fluorescence-based Förster resonance energy transfer. However, applications of MRET technology in vivo are currently limited by the moderate contrast enhancement and stability of T1-based MRET probes. Here we report a new two-way magnetic resonance tuning (TMRET) nanoprobe with dually activatable T1 and T2 magnetic resonance signals that is coupled with dual-contrast enhanced subtraction imaging. This integrated platform achieves a substantially improved contrast enhancement with minimal background signal and can be used to quantitatively image molecular targets in tumours and to sensitively detect very small intracranial brain tumours in patient-derived xenograft models. The high tumour-to-normal tissue ratio offered by TMRET in combination with dual-contrast enhanced subtraction imaging provides new opportunities for molecular diagnostics and image-guided biomedical applications.

Original languageEnglish (US)
JournalNature Nanotechnology
DOIs
StateAccepted/In press - Jan 1 2020

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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    Wang, Z., Xue, X., Lu, H., He, Y., Lu, Z., Chen, Z., Yuan, Y., Tang, N., Dreyer, C. A., Quigley, L., Curro, N., Lam, K. S., Walton, J. H., Lin, T. Y., Louie, A. Y., Gilbert, D. A., Liu, K., Ferrara, K. W., & Li, Y. (Accepted/In press). Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging. Nature Nanotechnology. https://doi.org/10.1038/s41565-020-0678-5