Abstract
BACKGROUND. In combination with other Commission on Cancer programs, the National Cancer Data Base (NCDB), a national electronic registry system currently capturing > 60% of incident cancers in the U. S., offers a working example of voluntary, accurate, cost-effective 'outcomes management' on a both a local and national scale. In addition, it is proving to be of particular value in capturing clinical information concerning rare cancers. METHODS. For accession years 1985-1995, the NCDB captured prospectively collected demographic, stage, treatment, and outcome information for a national hospital-based sample of 286 parathyroid carcinoma cases (0.005% of the total NCDB cancer cases). This report describes clinical and demographic features as well as patterns of care and 5-year and 10-year relative survival rates. RESULTS. The NCDB's 10-year accrual of parathyroid carcinoma cases exceeded the cumulative number reported in the English literature though 1991. Gender distribution was equal. The authors were unable to detect any disproportionate clustering by race, income level, or geographic region. Treatment overwhelmingly was surgical. The data from the current study suggest that neither tumor size nor lymph node status are significant prognostic factors. Overall relative survival at 5 years and 10 years was 85.5% and 49.1%, respectively. CONCLUSIONS. At 5 years of follow-up, and possibly beyond, neither tumor size nor lymph node status were found to be significant prognostic factors and basing a staging system on them would be useless. Although complete, en bloc resection of all tumor represents the best opportunity for cure, a substantial proportion of patients fail to receive such treatment. The authors speculate that the rarity of this condition and late intraoperative recognition occasionally prevent optimal treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 538-544 |
| Number of pages | 7 |
| Journal | Cancer |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 1 1999 |
| Externally published | Yes |
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Keywords
- National Cancer Data Base
- Parathyroid carcinoma
- Surgery
- Survival
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995 : A National Cancer Data Base report. / Hundahl, Scott A; Fleming, Irvin D.; Fremgen, Amy M.; Menck, Herman R.
In: Cancer, Vol. 86, No. 3, 01.08.1999, p. 538-544.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995
T2 - A National Cancer Data Base report
AU - Hundahl, Scott A
AU - Fleming, Irvin D.
AU - Fremgen, Amy M.
AU - Menck, Herman R.
PY - 1999/8/1
Y1 - 1999/8/1
N2 - BACKGROUND. In combination with other Commission on Cancer programs, the National Cancer Data Base (NCDB), a national electronic registry system currently capturing > 60% of incident cancers in the U. S., offers a working example of voluntary, accurate, cost-effective 'outcomes management' on a both a local and national scale. In addition, it is proving to be of particular value in capturing clinical information concerning rare cancers. METHODS. For accession years 1985-1995, the NCDB captured prospectively collected demographic, stage, treatment, and outcome information for a national hospital-based sample of 286 parathyroid carcinoma cases (0.005% of the total NCDB cancer cases). This report describes clinical and demographic features as well as patterns of care and 5-year and 10-year relative survival rates. RESULTS. The NCDB's 10-year accrual of parathyroid carcinoma cases exceeded the cumulative number reported in the English literature though 1991. Gender distribution was equal. The authors were unable to detect any disproportionate clustering by race, income level, or geographic region. Treatment overwhelmingly was surgical. The data from the current study suggest that neither tumor size nor lymph node status are significant prognostic factors. Overall relative survival at 5 years and 10 years was 85.5% and 49.1%, respectively. CONCLUSIONS. At 5 years of follow-up, and possibly beyond, neither tumor size nor lymph node status were found to be significant prognostic factors and basing a staging system on them would be useless. Although complete, en bloc resection of all tumor represents the best opportunity for cure, a substantial proportion of patients fail to receive such treatment. The authors speculate that the rarity of this condition and late intraoperative recognition occasionally prevent optimal treatment.
AB - BACKGROUND. In combination with other Commission on Cancer programs, the National Cancer Data Base (NCDB), a national electronic registry system currently capturing > 60% of incident cancers in the U. S., offers a working example of voluntary, accurate, cost-effective 'outcomes management' on a both a local and national scale. In addition, it is proving to be of particular value in capturing clinical information concerning rare cancers. METHODS. For accession years 1985-1995, the NCDB captured prospectively collected demographic, stage, treatment, and outcome information for a national hospital-based sample of 286 parathyroid carcinoma cases (0.005% of the total NCDB cancer cases). This report describes clinical and demographic features as well as patterns of care and 5-year and 10-year relative survival rates. RESULTS. The NCDB's 10-year accrual of parathyroid carcinoma cases exceeded the cumulative number reported in the English literature though 1991. Gender distribution was equal. The authors were unable to detect any disproportionate clustering by race, income level, or geographic region. Treatment overwhelmingly was surgical. The data from the current study suggest that neither tumor size nor lymph node status are significant prognostic factors. Overall relative survival at 5 years and 10 years was 85.5% and 49.1%, respectively. CONCLUSIONS. At 5 years of follow-up, and possibly beyond, neither tumor size nor lymph node status were found to be significant prognostic factors and basing a staging system on them would be useless. Although complete, en bloc resection of all tumor represents the best opportunity for cure, a substantial proportion of patients fail to receive such treatment. The authors speculate that the rarity of this condition and late intraoperative recognition occasionally prevent optimal treatment.
KW - National Cancer Data Base
KW - Parathyroid carcinoma
KW - Surgery
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=0033179565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033179565&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K
DO - 10.1002/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K
M3 - Article
C2 - 10430265
AN - SCOPUS:0033179565
VL - 86
SP - 538
EP - 544
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 3
ER -