Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995

A National Cancer Data Base report

Scott A Hundahl, Irvin D. Fleming, Amy M. Fremgen, Herman R. Menck

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

BACKGROUND. In combination with other Commission on Cancer programs, the National Cancer Data Base (NCDB), a national electronic registry system currently capturing > 60% of incident cancers in the U. S., offers a working example of voluntary, accurate, cost-effective 'outcomes management' on a both a local and national scale. In addition, it is proving to be of particular value in capturing clinical information concerning rare cancers. METHODS. For accession years 1985-1995, the NCDB captured prospectively collected demographic, stage, treatment, and outcome information for a national hospital-based sample of 286 parathyroid carcinoma cases (0.005% of the total NCDB cancer cases). This report describes clinical and demographic features as well as patterns of care and 5-year and 10-year relative survival rates. RESULTS. The NCDB's 10-year accrual of parathyroid carcinoma cases exceeded the cumulative number reported in the English literature though 1991. Gender distribution was equal. The authors were unable to detect any disproportionate clustering by race, income level, or geographic region. Treatment overwhelmingly was surgical. The data from the current study suggest that neither tumor size nor lymph node status are significant prognostic factors. Overall relative survival at 5 years and 10 years was 85.5% and 49.1%, respectively. CONCLUSIONS. At 5 years of follow-up, and possibly beyond, neither tumor size nor lymph node status were found to be significant prognostic factors and basing a staging system on them would be useless. Although complete, en bloc resection of all tumor represents the best opportunity for cure, a substantial proportion of patients fail to receive such treatment. The authors speculate that the rarity of this condition and late intraoperative recognition occasionally prevent optimal treatment.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalCancer
Volume86
Issue number3
DOIs
StatePublished - Aug 1 1999
Externally publishedYes

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Parathyroid Neoplasms
Databases
Neoplasms
Lymph Nodes
Demography
Literature
Cluster Analysis
Registries
Therapeutics
Survival Rate
Costs and Cost Analysis

Keywords

  • National Cancer Data Base
  • Parathyroid carcinoma
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995 : A National Cancer Data Base report. / Hundahl, Scott A; Fleming, Irvin D.; Fremgen, Amy M.; Menck, Herman R.

In: Cancer, Vol. 86, No. 3, 01.08.1999, p. 538-544.

Research output: Contribution to journalArticle

Hundahl, Scott A ; Fleming, Irvin D. ; Fremgen, Amy M. ; Menck, Herman R. / Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995 : A National Cancer Data Base report. In: Cancer. 1999 ; Vol. 86, No. 3. pp. 538-544.
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abstract = "BACKGROUND. In combination with other Commission on Cancer programs, the National Cancer Data Base (NCDB), a national electronic registry system currently capturing > 60{\%} of incident cancers in the U. S., offers a working example of voluntary, accurate, cost-effective 'outcomes management' on a both a local and national scale. In addition, it is proving to be of particular value in capturing clinical information concerning rare cancers. METHODS. For accession years 1985-1995, the NCDB captured prospectively collected demographic, stage, treatment, and outcome information for a national hospital-based sample of 286 parathyroid carcinoma cases (0.005{\%} of the total NCDB cancer cases). This report describes clinical and demographic features as well as patterns of care and 5-year and 10-year relative survival rates. RESULTS. The NCDB's 10-year accrual of parathyroid carcinoma cases exceeded the cumulative number reported in the English literature though 1991. Gender distribution was equal. The authors were unable to detect any disproportionate clustering by race, income level, or geographic region. Treatment overwhelmingly was surgical. The data from the current study suggest that neither tumor size nor lymph node status are significant prognostic factors. Overall relative survival at 5 years and 10 years was 85.5{\%} and 49.1{\%}, respectively. CONCLUSIONS. At 5 years of follow-up, and possibly beyond, neither tumor size nor lymph node status were found to be significant prognostic factors and basing a staging system on them would be useless. Although complete, en bloc resection of all tumor represents the best opportunity for cure, a substantial proportion of patients fail to receive such treatment. The authors speculate that the rarity of this condition and late intraoperative recognition occasionally prevent optimal treatment.",
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