Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection

Koen K.A. Van Rompay, Christopher J. Berardi, Nancy L. Aguirre, Norbert Bischofberger, Paul S. Lietman, Niels C Pedersen, Marta Marthas

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: Simple and affordable intervention strategies are needed to reduce the rate of HIV transmission from mother to infant in developing countries. Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is considered to be a useful model of human pediatric HIV infection. Objective: To investigate whether short-term 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) administration can protect newborn rhesus macaques against perinatal SIV infection. Design and methods: Eight newborn macaques were inoculated orally with highly virulent SIV(mac) within the first 3 days of life. Four of these animals were untreated controls. The other four animals were given one dose of PMPA (30 mg/kg subcutaneously) 4 h before oral SIV inoculation, and were then given a second and final dose of PMPA 24 h later. Results: All four untreated control animals were persistently SIV-positive within 2 weeks after virus inoculation. In contrast, no virus could be detected in the four animals that received two doses of PMPA; these animals were seronegative and healthy at 10 months. Conclusions: Two doses of PMPA prevented SIV infection of newborn macaques. Our data suggest that short-term administration of PMPA to HIV-infected pregnant women at the onset of labor and to their newborns after delivery may reduce the rate of intrapartum HIV transmission.

Original languageEnglish (US)
JournalAIDS
Volume12
Issue number9
StatePublished - Jun 18 1998

Fingerprint

Simian Immunodeficiency Virus
Macaca
Adenine
Virus Diseases
HIV
Macaca mulatta
Viruses
Labor Onset
Developing Countries
HIV Infections
Pregnant Women
Mothers
Newborn Infant
Pediatrics

Keywords

  • 9-[2-(phosphonomethoxy)propyl]adenine
  • Animal model
  • Pediatrics
  • Prevention
  • Primate
  • Prophylaxis
  • Simian immunodeficiency virus
  • Vertical transmission

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Van Rompay, K. K. A., Berardi, C. J., Aguirre, N. L., Bischofberger, N., Lietman, P. S., Pedersen, N. C., & Marthas, M. (1998). Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection. AIDS, 12(9).

Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection. / Van Rompay, Koen K.A.; Berardi, Christopher J.; Aguirre, Nancy L.; Bischofberger, Norbert; Lietman, Paul S.; Pedersen, Niels C; Marthas, Marta.

In: AIDS, Vol. 12, No. 9, 18.06.1998.

Research output: Contribution to journalArticle

Van Rompay, KKA, Berardi, CJ, Aguirre, NL, Bischofberger, N, Lietman, PS, Pedersen, NC & Marthas, M 1998, 'Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection', AIDS, vol. 12, no. 9.
Van Rompay KKA, Berardi CJ, Aguirre NL, Bischofberger N, Lietman PS, Pedersen NC et al. Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection. AIDS. 1998 Jun 18;12(9).
Van Rompay, Koen K.A. ; Berardi, Christopher J. ; Aguirre, Nancy L. ; Bischofberger, Norbert ; Lietman, Paul S. ; Pedersen, Niels C ; Marthas, Marta. / Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection. In: AIDS. 1998 ; Vol. 12, No. 9.
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