Two decades of cytoplasmic dynein: From fast to forceful

Richard Mckenney, Richard B. Vallee

Research output: Chapter in Book/Report/Conference proceedingChapter


Although cytoplasmic dynein probably appeared first during evolution, its discovery did not occur until research into axonemal dynein was well advanced. This chapter traces the initial discovery of cytoplasmic dynein as one of the high molecular weight microtubule associated proteins in brain, followed gradually by the identification of a versatile collection of dynein associated proteins. Various protein complexes significantly modulate the properties of cytoplasmic dynein and its interaction with diferent cargoes. The focus in this chapter is on the way that these properties have been investigated in vitro.

Original languageEnglish (US)
Title of host publicationHandbook of Dynein
PublisherPan Stanford Publishing Pte. Ltd.
Number of pages15
ISBN (Print)9789814303330
StatePublished - Nov 30 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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