Two cases of mantle cell lymphoma mimicking marginal zone lymphoma

Xiangdong Xu, Huan You Wang, Hooman Rashidi, Anna K. Wong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mantle cell lymphoma (MCL) is a B cell lymphoma with four morphologic variants recognized by the current World Health Organization classification. MCL mimicking marginal zone lymphoma (MZL) (MCL mimicking MZL) is the rarest variant and could be a potential diagnostic pitfall due to its deceiving "monocytoid" appearance. We report two cases of extranodal MCL mimicking MZL occurring at different sites-the oropharynx and the rectosigmoid colon. Both cases showed unexpected diffuse submucosal lymphoid infiltration of small- to medium-sized lymphocytes with focal monocytoid appearance. Immunohistochemistry showed the presence of an abnormal CD5(-)/CD10(-) B cell population expressing cyclin D1. The diagnosis of MCL was further substantiated by cytogenetic evidence of t(11;14)(q13;q32). Ki-67 proliferation indexes of both cases were low. In summary, MCL mimicking MZL may have unusual morphologic and immunophenotypic characteristics that could be a diagnostic pitfall.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalJournal of Hematopathology
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2012

Fingerprint

Mantle-Cell Lymphoma
Lymphoma
Oropharynx
Cyclin D1
B-Cell Lymphoma
Cytogenetics
Colon
B-Lymphocytes
Immunohistochemistry
Lymphocytes
Population

Keywords

  • CD5 negativity
  • Mantle cell lymphoma
  • Mantle cell lymphoma mimicking marginal zone lymphoma
  • t(11;14)(q13;q32)/CCND1-IGH

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

Cite this

Two cases of mantle cell lymphoma mimicking marginal zone lymphoma. / Xu, Xiangdong; Wang, Huan You; Rashidi, Hooman; Wong, Anna K.

In: Journal of Hematopathology, Vol. 5, No. 4, 01.12.2012, p. 335-340.

Research output: Contribution to journalArticle

Xu, Xiangdong ; Wang, Huan You ; Rashidi, Hooman ; Wong, Anna K. / Two cases of mantle cell lymphoma mimicking marginal zone lymphoma. In: Journal of Hematopathology. 2012 ; Vol. 5, No. 4. pp. 335-340.
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