Abstract
Mantle cell lymphoma (MCL) is a B cell lymphoma with four morphologic variants recognized by the current World Health Organization classification. MCL mimicking marginal zone lymphoma (MZL) (MCL mimicking MZL) is the rarest variant and could be a potential diagnostic pitfall due to its deceiving "monocytoid" appearance. We report two cases of extranodal MCL mimicking MZL occurring at different sites-the oropharynx and the rectosigmoid colon. Both cases showed unexpected diffuse submucosal lymphoid infiltration of small- to medium-sized lymphocytes with focal monocytoid appearance. Immunohistochemistry showed the presence of an abnormal CD5(-)/CD10(-) B cell population expressing cyclin D1. The diagnosis of MCL was further substantiated by cytogenetic evidence of t(11;14)(q13;q32). Ki-67 proliferation indexes of both cases were low. In summary, MCL mimicking MZL may have unusual morphologic and immunophenotypic characteristics that could be a diagnostic pitfall.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-340 |
| Number of pages | 6 |
| Journal | Journal of Hematopathology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2012 |
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Keywords
- CD5 negativity
- Mantle cell lymphoma
- Mantle cell lymphoma mimicking marginal zone lymphoma
- t(11;14)(q13;q32)/CCND1-IGH
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Hematology
Cite this
Two cases of mantle cell lymphoma mimicking marginal zone lymphoma. / Xu, Xiangdong; Wang, Huan You; Rashidi, Hooman; Wong, Anna K.
In: Journal of Hematopathology, Vol. 5, No. 4, 01.12.2012, p. 335-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two cases of mantle cell lymphoma mimicking marginal zone lymphoma
AU - Xu, Xiangdong
AU - Wang, Huan You
AU - Rashidi, Hooman
AU - Wong, Anna K.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Mantle cell lymphoma (MCL) is a B cell lymphoma with four morphologic variants recognized by the current World Health Organization classification. MCL mimicking marginal zone lymphoma (MZL) (MCL mimicking MZL) is the rarest variant and could be a potential diagnostic pitfall due to its deceiving "monocytoid" appearance. We report two cases of extranodal MCL mimicking MZL occurring at different sites-the oropharynx and the rectosigmoid colon. Both cases showed unexpected diffuse submucosal lymphoid infiltration of small- to medium-sized lymphocytes with focal monocytoid appearance. Immunohistochemistry showed the presence of an abnormal CD5(-)/CD10(-) B cell population expressing cyclin D1. The diagnosis of MCL was further substantiated by cytogenetic evidence of t(11;14)(q13;q32). Ki-67 proliferation indexes of both cases were low. In summary, MCL mimicking MZL may have unusual morphologic and immunophenotypic characteristics that could be a diagnostic pitfall.
AB - Mantle cell lymphoma (MCL) is a B cell lymphoma with four morphologic variants recognized by the current World Health Organization classification. MCL mimicking marginal zone lymphoma (MZL) (MCL mimicking MZL) is the rarest variant and could be a potential diagnostic pitfall due to its deceiving "monocytoid" appearance. We report two cases of extranodal MCL mimicking MZL occurring at different sites-the oropharynx and the rectosigmoid colon. Both cases showed unexpected diffuse submucosal lymphoid infiltration of small- to medium-sized lymphocytes with focal monocytoid appearance. Immunohistochemistry showed the presence of an abnormal CD5(-)/CD10(-) B cell population expressing cyclin D1. The diagnosis of MCL was further substantiated by cytogenetic evidence of t(11;14)(q13;q32). Ki-67 proliferation indexes of both cases were low. In summary, MCL mimicking MZL may have unusual morphologic and immunophenotypic characteristics that could be a diagnostic pitfall.
KW - CD5 negativity
KW - Mantle cell lymphoma
KW - Mantle cell lymphoma mimicking marginal zone lymphoma
KW - t(11;14)(q13;q32)/CCND1-IGH
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U2 - 10.1007/s12308-012-0147-7
DO - 10.1007/s12308-012-0147-7
M3 - Article
VL - 5
SP - 335
EP - 340
JO - Journal of Hematopathology
JF - Journal of Hematopathology
SN - 1865-5785
IS - 4
ER -