Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horse

Arne Ludwig, Monika Reissmann, Norbert Benecke, Rebecca Bellone, Edson Sandoval-Castellanos, Michael Cieslak, Gloria G. Fortes, Arturo Morales-Muñiz, Michael Hofreiter, Melanie Pruvost

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Leopard complex spotting is inherited by the incompletely dominant locus, LP, which also causes congenital stationary night blindness in homozygous horses. We investigated an associated single nucleotide polymorphism in the TRPM1 gene in 96 archaeological bones from 31 localities from Late Pleistocene (approx. 17 000 YBP) to medieval times. The first genetic evidence of LP spotting in Europe dates back to the Pleistocene. We tested for temporal changes in the LP associated allele frequency and estimated coefficients of selection by means of approximate Bayesian computation analyses. Our results show that at least some of the observed frequency changes are congruent with shifts in artificial selection pressure for the leopard complex spotting phenotype. In early domestic horses from Kirklareli–Kanligecit (Turkey) dating to 2700–2200 BC, a remarkably high number of leopard spotted horses (six of 10 individuals) was detected including one adult homozygote. However, LP seems to have largely disappeared during the late Bronze Age, suggesting selection against this phenotype in early domestic horses. During the Iron Age, LP reappeared, probably by reintroduction into the domestic gene pool from wild animals. This picture of alternating selective regimes might explain how genetic diversity was maintained in domestic animals despite selection for specific traits at different times.

Original languageEnglish (US)
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume370
Issue number1660
DOIs
StatePublished - Jan 19 2015

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Panthera
night blindness
Night Blindness
Metrorrhagia
Horses
Animals
Genes
horses
Bronze
Polymorphism
Bone
Nucleotides
Iron
Phenotype
Gene Pool
phenotype
Wild Animals
artificial selection
Bayes Theorem
Domestic Animals

Keywords

  • Ancient DNA
  • Coat colour
  • Domestication
  • Equus
  • Palaeogenetics
  • Populatio

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horse. / Ludwig, Arne; Reissmann, Monika; Benecke, Norbert; Bellone, Rebecca; Sandoval-Castellanos, Edson; Cieslak, Michael; Fortes, Gloria G.; Morales-Muñiz, Arturo; Hofreiter, Michael; Pruvost, Melanie.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 370, No. 1660, 19.01.2015.

Research output: Contribution to journalArticle

Ludwig, A, Reissmann, M, Benecke, N, Bellone, R, Sandoval-Castellanos, E, Cieslak, M, Fortes, GG, Morales-Muñiz, A, Hofreiter, M & Pruvost, M 2015, 'Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horse', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 370, no. 1660. https://doi.org/10.1098/rstb.2013.0386
Ludwig, Arne ; Reissmann, Monika ; Benecke, Norbert ; Bellone, Rebecca ; Sandoval-Castellanos, Edson ; Cieslak, Michael ; Fortes, Gloria G. ; Morales-Muñiz, Arturo ; Hofreiter, Michael ; Pruvost, Melanie. / Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horse. In: Philosophical Transactions of the Royal Society B: Biological Sciences. 2015 ; Vol. 370, No. 1660.
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