Tutorial on chip-based electrophysiology to assess ion channel function

Huilan Han, Cristina E Davis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ion channels are one of the most important categories of proteins in animal and plant physiology. Their function dictates activities as far reaching as controlling transmembrane potential in the nervous system to regulating plant cell volumes in extreme environments. The functionality of these proteins is notoriously difficult to assess, and there is a great demand for high throughput measurement systems which can monitor channel activity in cellular systems. There have been significant recent advances in the field of chip-based electrophysiology, especially microfabricated patch-clamp systems. Our research group is currently pursuing research in this area, and here we provide a tutorial that summarizes all of the relevant work in the field to date. We have also noted areas where we feel that future research in the field is likely to provide improvements in device design, manufacturability and testing of these interesting and important devices.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume6768
DOIs
StatePublished - 2007
EventNanomaterials Synthesis, Interfacing, and Integrating in Devices, Circuits, and Systems II - Boston, MA, United States
Duration: Sep 9 2007Sep 11 2007

Other

OtherNanomaterials Synthesis, Interfacing, and Integrating in Devices, Circuits, and Systems II
CountryUnited States
CityBoston, MA
Period9/9/079/11/07

Keywords

  • Biosensors
  • Ion channel
  • Microelectromechanical system (MEMS)
  • Nanotechnology
  • Patch clamp

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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