Tumour localisation of 211At-labelled monoclonal antibody to a sub-cutaneous human heterograft in the nude mouse II

W. J. Bateman, Andrew T M Vaughan, G. Brown

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A monoclonal antibody covalently labelled with the radiotoxic isotope 211At, has been shown to specifically localise to the site of human heterograft tumours growing in nude mice. The monoclonal antibody BK 19.9 shows specificity for the human transferrin receptor, and therefore binds to the majority of rapidly dividing human cell lines. Balb/c nude mice bearing s.c. HL60 (human promyelocytic) tumour nodules were injected intravenously with 0.1-0.3μCi (3-9 μg) of 211At-labelled BK 19.9 antibody mixed with an equivalent amount of an 125I-labelled control mouse immunoglobulin. A specific tumour localisation of 2-5 × that seen in any other tissue was obtained at 12 h post-injection asidetermined by the ratio of specific to non-specific immunoglobulin in each tissue. While it is possible to make reliable predictions of the tissue dose with a known radioisotope distribution in vivo, further studies are required to determine the potential therapeutic value of these reagents in the selective destruction of tumour deposits.

Original languageEnglish (US)
Pages (from-to)241-244
Number of pages4
JournalInternational Journal of Nuclear Medicine and Biology
Volume10
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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