Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer

Tzu-Yin Lin, Yuanpei Li, Hongyong Zhang, Juntao Luo, Neal Goodwin, Tingjuan Gao, Ralph W deVere White, Kit Lam, Chong-Xian Pan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aim: This work aimed to determine if the treatment outcomes of bladder cancer could be improved by targeting micelles that are decorated with bladder cancer-specific ligands on the surface and loaded with the chemotherapeutic drug paclitaxel. Materials & methods: Targeting efficacy and specificity was determined with cell lines. An in vivo targeting and anti-tumor efficacy study was conducted in mice carrying patient-derived xenografts. Results & discussion: Targeting micelles were more efficient than nontargeting micelles in delivering the drug load into bladder cancer cells both in vitro and in vivo (p < 0.05). The micelle formulation of paclitaxel was less toxic than free paclitaxel in Cremophor® (Sigma, MO, USA) and allowed administration of three-times the maximum tolerated dose without increasing the toxicity. Targeting micelles were more effective than the nontargeting micelles in controlling cancer growth (p = 0.0002) and prolonging overall survival (p = 0.002). Conclusion: Targeting micelles loaded with paclitaxel offer strong potential for clinical applications in treating bladder cancer. Original submitted 16 March 2012; Revised submitted 30 August 2012; Published online 2 December 201.

Original languageEnglish (US)
Pages (from-to)1239-1251
Number of pages13
JournalNanomedicine
Volume8
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

chemotherapy
Chemotherapy
Micelles
Urinary Bladder Neoplasms
tumor
targeting
Tumors
cancer
Imaging techniques
Drug Therapy
Paclitaxel
Neoplasms
drug
Cells
Maximum Tolerated Dose
Poisons
ligand
Heterografts
Pharmaceutical Preparations
Toxicity

Keywords

  • bladder cancer-specific ligand
  • bladder urothelial carcinoma
  • diagnostic imaging
  • nanoparticle
  • targeted therapy

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

Cite this

Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer. / Lin, Tzu-Yin; Li, Yuanpei; Zhang, Hongyong; Luo, Juntao; Goodwin, Neal; Gao, Tingjuan; deVere White, Ralph W; Lam, Kit; Pan, Chong-Xian.

In: Nanomedicine, Vol. 8, No. 8, 08.2013, p. 1239-1251.

Research output: Contribution to journalArticle

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