Tumor suppression by p53: Making cells senescent

Yingjuan Qian, Xinbin Chen

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Cellular senescence is a permanent cell cycle arrest and a potent tumor suppression mechanism. The p53 tumor suppressor is a sequence-specific transcription factor and acts as a central hub sensing various stress signals and activating an array of target genes to induce cell cycle arrest, apoptosis, and senescence. Recent reports showed that restoration of p53 induces premature senescence and tumor regression in mice with hepatocarcinomas or sarcomas. Thus, p53-mediated senescence is capable of eliminating cancer cells in vivo. p63 and p73, two homologues of p53, have similar function in cell cycle arrest and apoptosis. However, the role of p63 and p73 in cellular senescence is elusive. In this review, we will discuss how p53 regulates senescence and future studies about p53 family members in senescence.

Original languageEnglish (US)
Pages (from-to)515-526
Number of pages12
JournalHistology and Histopathology
Volume25
Issue number4
StatePublished - Apr 2010

Keywords

  • Cellular senescence
  • P21
  • P53
  • Tumor Suppression

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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