Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

P. Rieckmann; Joseph Tuscano; J. H. Kehrl

doi:10.1006/meth.1996.0396

Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

P. Rieckmann, Joseph Tuscano, J. H. Kehrl

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.

Original language	English (US)
Pages (from-to)	128-132
Number of pages	5
Journal	Methods: A Companion to Methods in Enzymology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1006/meth.1996.0396
State	Published - Jan 1997
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)

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10.1006/meth.1996.0396

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abstract = "Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.",

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AB - Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.

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Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

Abstract

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