Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

P. Rieckmann; Joseph Tuscano; J. H. Kehrl

doi:10.1006/meth.1996.0396

Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

P. Rieckmann, Joseph Tuscano, J. H. Kehrl

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.

Original language	English (US)
Pages (from-to)	128-132
Number of pages	5
Journal	Methods: A Companion to Methods in Enzymology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1006/meth.1996.0396
State	Published - Jan 1997
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1006/meth.1996.0396

Cite this

@article{c8d05cc651d246d7abdad15db943ba6f,

title = "Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function",

abstract = "Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.",

author = "P. Rieckmann and Joseph Tuscano and Kehrl, {J. H.}",

year = "1997",

month = jan,

doi = "10.1006/meth.1996.0396",

language = "English (US)",

volume = "11",

pages = "128--132",

journal = "Methods",

issn = "0076-6879",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

AU - Rieckmann, P.

AU - Tuscano, Joseph

AU - Kehrl, J. H.

PY - 1997/1

Y1 - 1997/1

N2 - Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.

AB - Two cytokines important in the regulation of B-cell function are tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). They act at different steps in B-cell differentiation and can be produced by the B cells themselves upon appropriate stimulation. Crosslinking of surface Ig and signaling through CD22 or CD40 lead to increased secretion of both cytokines. Neutralization of TNF-α or IL-6 biologic activity in B-cell cultures results in a significant reduction in B-cell proliferation and Ig secretion. Increased production of these cytokines is found in several diseases associated with aberrant B-cell function. This review will focus on the role of TNF-α and IL-6 in normal and pathophysiological conditions of B-cell function.

UR - http://www.scopus.com/inward/record.url?scp=0030927848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030927848&partnerID=8YFLogxK

U2 - 10.1006/meth.1996.0396

DO - 10.1006/meth.1996.0396

M3 - Article

C2 - 8990098

AN - SCOPUS:0030927848

VL - 11

SP - 128

EP - 132

JO - Methods

JF - Methods

SN - 0076-6879

IS - 1

ER -

Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in B-lymphocyte function

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this