Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A 25-year experience at a single institution

Eveline Shue, Marjan Bolouri, Eric B. Jelin, Lan Vu, Barbara Bratton, Elizabeth Cedars, Leah Yoke, Francesca Byrne, Shinjiro Hirose, Vickie Feldstein, Doug Miniati, Hanmin Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose Some fetuses with sacrococcygeal teratoma (SCT) develop hydrops, but there is no consensus on an appropriate prognostic marker for poor prognosis. The purpose of this study is to establish predictors of poor prognosis in fetuses with SCT. Methods A retrospective review of patients with prenatally diagnosed SCT from 1986 to 2011 was performed. Patients with outcome data and ultrasound exams before 32 weeks gestational age (GA) were included (n = 37). Tumor volume-to-fetal weight ratio (TFR) and tumor morphology were assessed as sonographic predictors of poor prognosis. Results Twelve patients (32%) had good prognosis, and twenty-five patients (68%) had poor prognosis. All patients with poor prognosis had a morphology score ≥ 3, which is a significant predictor of poor prognosis (p < 0.0001). TFR was assessed, and a receiver operating characteristic (ROC) analysis identified a cutoff value of 0.12 before 24 weeks GA and 0.11 before 32 weeks GA as predictors for poor prognosis. TFR is a significant predictor of poor prognosis (p < 0.0001). Conclusions Patients with cystic SCT all had good prognosis. TFR > 0.12 was validated as a sonographic predictor of poor prognosis. TFR and tumor morphology can be used to counsel expectant families with prenatally diagnosed SCT regarding prognosis.

Original languageEnglish (US)
Pages (from-to)1225-1231
Number of pages7
JournalJournal of Pediatric Surgery
Volume48
Issue number6
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

Fingerprint

Teratoma
Neoplasms
Fetal Weight
Fetus
Tumor Burden
Gestational Age
Edema
Consensus

Keywords

  • Hydrops
  • Sacrococcygeal teratoma
  • SCT
  • TFR
  • Tumor morphology

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma : A 25-year experience at a single institution. / Shue, Eveline; Bolouri, Marjan; Jelin, Eric B.; Vu, Lan; Bratton, Barbara; Cedars, Elizabeth; Yoke, Leah; Byrne, Francesca; Hirose, Shinjiro; Feldstein, Vickie; Miniati, Doug; Lee, Hanmin.

In: Journal of Pediatric Surgery, Vol. 48, No. 6, 01.06.2013, p. 1225-1231.

Research output: Contribution to journalArticle

Shue, E, Bolouri, M, Jelin, EB, Vu, L, Bratton, B, Cedars, E, Yoke, L, Byrne, F, Hirose, S, Feldstein, V, Miniati, D & Lee, H 2013, 'Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A 25-year experience at a single institution', Journal of Pediatric Surgery, vol. 48, no. 6, pp. 1225-1231. https://doi.org/10.1016/j.jpedsurg.2013.03.016
Shue, Eveline ; Bolouri, Marjan ; Jelin, Eric B. ; Vu, Lan ; Bratton, Barbara ; Cedars, Elizabeth ; Yoke, Leah ; Byrne, Francesca ; Hirose, Shinjiro ; Feldstein, Vickie ; Miniati, Doug ; Lee, Hanmin. / Tumor metrics and morphology predict poor prognosis in prenatally diagnosed sacrococcygeal teratoma : A 25-year experience at a single institution. In: Journal of Pediatric Surgery. 2013 ; Vol. 48, No. 6. pp. 1225-1231.
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abstract = "Purpose Some fetuses with sacrococcygeal teratoma (SCT) develop hydrops, but there is no consensus on an appropriate prognostic marker for poor prognosis. The purpose of this study is to establish predictors of poor prognosis in fetuses with SCT. Methods A retrospective review of patients with prenatally diagnosed SCT from 1986 to 2011 was performed. Patients with outcome data and ultrasound exams before 32 weeks gestational age (GA) were included (n = 37). Tumor volume-to-fetal weight ratio (TFR) and tumor morphology were assessed as sonographic predictors of poor prognosis. Results Twelve patients (32{\%}) had good prognosis, and twenty-five patients (68{\%}) had poor prognosis. All patients with poor prognosis had a morphology score ≥ 3, which is a significant predictor of poor prognosis (p < 0.0001). TFR was assessed, and a receiver operating characteristic (ROC) analysis identified a cutoff value of 0.12 before 24 weeks GA and 0.11 before 32 weeks GA as predictors for poor prognosis. TFR is a significant predictor of poor prognosis (p < 0.0001). Conclusions Patients with cystic SCT all had good prognosis. TFR > 0.12 was validated as a sonographic predictor of poor prognosis. TFR and tumor morphology can be used to counsel expectant families with prenatally diagnosed SCT regarding prognosis.",
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T2 - A 25-year experience at a single institution

AU - Shue, Eveline

AU - Bolouri, Marjan

AU - Jelin, Eric B.

AU - Vu, Lan

AU - Bratton, Barbara

AU - Cedars, Elizabeth

AU - Yoke, Leah

AU - Byrne, Francesca

AU - Hirose, Shinjiro

AU - Feldstein, Vickie

AU - Miniati, Doug

AU - Lee, Hanmin

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N2 - Purpose Some fetuses with sacrococcygeal teratoma (SCT) develop hydrops, but there is no consensus on an appropriate prognostic marker for poor prognosis. The purpose of this study is to establish predictors of poor prognosis in fetuses with SCT. Methods A retrospective review of patients with prenatally diagnosed SCT from 1986 to 2011 was performed. Patients with outcome data and ultrasound exams before 32 weeks gestational age (GA) were included (n = 37). Tumor volume-to-fetal weight ratio (TFR) and tumor morphology were assessed as sonographic predictors of poor prognosis. Results Twelve patients (32%) had good prognosis, and twenty-five patients (68%) had poor prognosis. All patients with poor prognosis had a morphology score ≥ 3, which is a significant predictor of poor prognosis (p < 0.0001). TFR was assessed, and a receiver operating characteristic (ROC) analysis identified a cutoff value of 0.12 before 24 weeks GA and 0.11 before 32 weeks GA as predictors for poor prognosis. TFR is a significant predictor of poor prognosis (p < 0.0001). Conclusions Patients with cystic SCT all had good prognosis. TFR > 0.12 was validated as a sonographic predictor of poor prognosis. TFR and tumor morphology can be used to counsel expectant families with prenatally diagnosed SCT regarding prognosis.

AB - Purpose Some fetuses with sacrococcygeal teratoma (SCT) develop hydrops, but there is no consensus on an appropriate prognostic marker for poor prognosis. The purpose of this study is to establish predictors of poor prognosis in fetuses with SCT. Methods A retrospective review of patients with prenatally diagnosed SCT from 1986 to 2011 was performed. Patients with outcome data and ultrasound exams before 32 weeks gestational age (GA) were included (n = 37). Tumor volume-to-fetal weight ratio (TFR) and tumor morphology were assessed as sonographic predictors of poor prognosis. Results Twelve patients (32%) had good prognosis, and twenty-five patients (68%) had poor prognosis. All patients with poor prognosis had a morphology score ≥ 3, which is a significant predictor of poor prognosis (p < 0.0001). TFR was assessed, and a receiver operating characteristic (ROC) analysis identified a cutoff value of 0.12 before 24 weeks GA and 0.11 before 32 weeks GA as predictors for poor prognosis. TFR is a significant predictor of poor prognosis (p < 0.0001). Conclusions Patients with cystic SCT all had good prognosis. TFR > 0.12 was validated as a sonographic predictor of poor prognosis. TFR and tumor morphology can be used to counsel expectant families with prenatally diagnosed SCT regarding prognosis.

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