Tumor-induced osteomalacia in a 3-year-old with unresectable central giant cell lesions

Stephanie Crossen, Eduardo Zambrano, Beverley Newman, Jonathan A. Bernstein, Anna H. Messner, Laura K. Bachrach, Clare J. Twist

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Tumor-induced osteomalacia (TIO) is a rare cause of hypophosphatemia involving overproduction of fibroblast growth factor 23. TIO has been described largely in adults with small mesenchymal tumors. We report a case of TIO in a child who presented with knee pain and radiographic findings concerning for rickets, and was found to have maxillomandibular giant cell lesions. The patient was treated with oral phosphorus and calcitriol, surgical debulking, and intralesional corticosteroids, which resulted in tumor regression and normalization of serum fibroblast growth factor 23 and phosphorus. This case illustrates the occurrence of this rare paraneoplastic syndrome in children and adds to our knowledge about clinical manifestations and pathologic findings associated with pediatric TIO.

Original languageEnglish (US)
Pages (from-to)e21-e24
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - Jan 1 2017
Externally publishedYes


  • Central giant cell lesion
  • Fibroblast growth factor 23
  • Tumor-induced osteomalacia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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