Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition - A Warburg-reversing effect

Agriculture & Biology

• hexokinase 94%
• oxidative phosphorylation 89%
• glycolysis 80%
• neoplasm cells 72%
• energy metabolism 43%
• lactates 20%
• mitochondria 17%
• glioblastoma 16%
• cancer therapy 16%
• rapamycin 14%
• colorectal neoplasms 13%
• breast neoplasms 12%
• cell respiration 11%
• oxygen consumption 10%
• cell proliferation 10%
• irradiation 9%
• therapeutics 8%
• neoplasms 8%
• cell lines 8%
• oxygen 7%
• glucose 6%
• energy 6%
• metabolism 6%
• dosage 5%

Medicine & Life Sciences

• Hexokinase 100%
• Oxidative Phosphorylation 88%
• Glycolysis 82%
• Radiation 59%
• Energy Metabolism 40%
• Neoplasms 25%
• Lactic Acid 20%
• Mitochondria 18%
• Mitochondrial Proteins 12%
• Sirolimus 11%
• Tumor Cell Line 11%
• Oxygen Consumption 11%
• Glioblastoma 11%
• Colonic Neoplasms 10%
• Respiration 9%
• Adenosine Triphosphate 8%
• Oxygen 8%
• Cell Proliferation 7%
• Breast Neoplasms 7%
• Glucose 7%

Chemical Compounds

• Pharmacological Metabolism 60%
• Lactate 53%
• Clonogenic 40%
• Energy 37%
• Genotoxic 31%
• Energy Consumption 28%
• Dioxygen 25%
• Enzyme Activity 21%
• Dose 20%
• Glucose 19%
• Protein 10%