Tumor biology in explanation of the failure of screening for cancer and in determination of future strategies

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Abstract

Screening examinations for so-called "early cancer" are popular methods to decrease cancer mortality. This report reviews current concepts in tumor biology that explain why screening for cancer succeeds and why it fails. From this review, three biologic subgroups emerge for many cancers. In only one of these groups will screening methods be successful in decreasing death from cancer. Breast cancer and prostatic cancer are specifically considered to support this hypothesis. Implications for future investigations and the impact on public policy are discussed.

Original languageEnglish (US)
Pages (from-to)911-916
Number of pages6
JournalThe American journal of medicine
Volume80
Issue number5
DOIs
StatePublished - 1986

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Early Detection of Cancer
Neoplasms
Public Policy
Prostatic Neoplasms
Breast Neoplasms
Mortality

ASJC Scopus subject areas

  • Nursing(all)

Cite this

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title = "Tumor biology in explanation of the failure of screening for cancer and in determination of future strategies",
abstract = "Screening examinations for so-called {"}early cancer{"} are popular methods to decrease cancer mortality. This report reviews current concepts in tumor biology that explain why screening for cancer succeeds and why it fails. From this review, three biologic subgroups emerge for many cancers. In only one of these groups will screening methods be successful in decreasing death from cancer. Breast cancer and prostatic cancer are specifically considered to support this hypothesis. Implications for future investigations and the impact on public policy are discussed.",
author = "Meyers, {Frederick J}",
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