Tumor and serum tamoxifen concentrations in the athymic nude mouse

Michael W. DeGregorio, Ester Coronado, C. Kent Osborne

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The athymic nude mouse has been used as an in vivo model for pharmacologic studies of the antiestrogen, tamoxifen. Serum and tumor tamoxifen and metabolite concentrations were examined during and after 100 and 1000 μg/day doses injected s.c. Tamoxifen and tamoxifen metabolites were quantitated by high-performance liquid chromatography. Tamoxifen was detected in tumors after a dose of 100 μg/day, although serum concentrations were not detected. At a dose of 1000 μg/day, tumor tamoxifen and its active metabolites were detected in high concentrations ranging up to >6 mmol/g tissue. Serum tamoxifen metabolites were not detected at either dose. In summary, high doses of tamoxifen were required in the nude mouse to obtain clinically relevant serum concentrations, and significant tumor levels were achieved at doses that resulted in undetectable serum levels. The relationship between serum tamoxifen concentrations, tumor tamoxifen levels, and the biologic activity of the drug requires further study.

Original languageEnglish (US)
Pages (from-to)68-70
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume23
Issue number2
DOIs
StatePublished - Feb 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Tumor and serum tamoxifen concentrations in the athymic nude mouse'. Together they form a unique fingerprint.

  • Cite this