Tularemia in range sheep

An overlooked syndrome?

Donal O'Toole, Elizabeth S. Williams, Leslie Woods, Kenneth Mills, Amy Boerger-Fields, Donald L. Montgomery, Paula Jaeger, William H. Edwards, Dwayne Christensen, William Marlatt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Abortion and death caused by Francisella tularensis were well recognized in range flocks of domestic sheep in Idaho, Montana, and Wyoming in the first 6 decades of the 20th century. The current report describes 4 episodes of tularemia in 3 range flocks in Wyoming and South Dakota in 1997 and 2007 (1 flock was affected twice). Flock owners reported that ticks were unusually numerous and commonly present on sheep during outbreaks. Tularemia presented as late-term abortions (3 episodes) or listlessness and death in lambs and, to a lesser extent, ewes (1 episode). Lesions were multifocal pinpoint necrotic foci in tissues, particularly spleen, liver, and lung. An immunohistochemical procedure demonstrated F. tularensis, particularly in necrotic foci. The diagnosis was corroborated by bacterial isolation and, in individual cases, by serology, fluorescent antibody assay, and/or polymerase chain reaction detection of F. tularensis. Diagnosticians in endemic areas should include tularemia as a differential diagnosis when investigating late-term abortions or outbreaks of fatal illness in young lambs, particularly in years of high tick activity and when characteristic necrotic foci occur in spleen, liver, and lung.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalJournal of Veterinary Diagnostic Investigation
Volume20
Issue number4
StatePublished - Jul 1 2008
Externally publishedYes

Fingerprint

tularemia
Francisella tularensis
Tularemia
abortion (animals)
Sheep
flocks
Ticks
sheep
Disease Outbreaks
Spleen
Domestic Sheep
ticks
Lung
spleen
lambs
Liver
lungs
Serology
death
liver

Keywords

  • Abortion
  • Diagnosis
  • Francisella tularensis
  • Immunohistochemistry
  • Sheep
  • South Dakota
  • Tularemia
  • Wood tick
  • Wyoming

ASJC Scopus subject areas

  • veterinary(all)

Cite this

O'Toole, D., Williams, E. S., Woods, L., Mills, K., Boerger-Fields, A., Montgomery, D. L., ... Marlatt, W. (2008). Tularemia in range sheep: An overlooked syndrome? Journal of Veterinary Diagnostic Investigation, 20(4), 508-513.

Tularemia in range sheep : An overlooked syndrome? / O'Toole, Donal; Williams, Elizabeth S.; Woods, Leslie; Mills, Kenneth; Boerger-Fields, Amy; Montgomery, Donald L.; Jaeger, Paula; Edwards, William H.; Christensen, Dwayne; Marlatt, William.

In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 4, 01.07.2008, p. 508-513.

Research output: Contribution to journalArticle

O'Toole, D, Williams, ES, Woods, L, Mills, K, Boerger-Fields, A, Montgomery, DL, Jaeger, P, Edwards, WH, Christensen, D & Marlatt, W 2008, 'Tularemia in range sheep: An overlooked syndrome?', Journal of Veterinary Diagnostic Investigation, vol. 20, no. 4, pp. 508-513.
O'Toole D, Williams ES, Woods L, Mills K, Boerger-Fields A, Montgomery DL et al. Tularemia in range sheep: An overlooked syndrome? Journal of Veterinary Diagnostic Investigation. 2008 Jul 1;20(4):508-513.
O'Toole, Donal ; Williams, Elizabeth S. ; Woods, Leslie ; Mills, Kenneth ; Boerger-Fields, Amy ; Montgomery, Donald L. ; Jaeger, Paula ; Edwards, William H. ; Christensen, Dwayne ; Marlatt, William. / Tularemia in range sheep : An overlooked syndrome?. In: Journal of Veterinary Diagnostic Investigation. 2008 ; Vol. 20, No. 4. pp. 508-513.
@article{775bf6b1fac444dd916529a6626f37be,
title = "Tularemia in range sheep: An overlooked syndrome?",
abstract = "Abortion and death caused by Francisella tularensis were well recognized in range flocks of domestic sheep in Idaho, Montana, and Wyoming in the first 6 decades of the 20th century. The current report describes 4 episodes of tularemia in 3 range flocks in Wyoming and South Dakota in 1997 and 2007 (1 flock was affected twice). Flock owners reported that ticks were unusually numerous and commonly present on sheep during outbreaks. Tularemia presented as late-term abortions (3 episodes) or listlessness and death in lambs and, to a lesser extent, ewes (1 episode). Lesions were multifocal pinpoint necrotic foci in tissues, particularly spleen, liver, and lung. An immunohistochemical procedure demonstrated F. tularensis, particularly in necrotic foci. The diagnosis was corroborated by bacterial isolation and, in individual cases, by serology, fluorescent antibody assay, and/or polymerase chain reaction detection of F. tularensis. Diagnosticians in endemic areas should include tularemia as a differential diagnosis when investigating late-term abortions or outbreaks of fatal illness in young lambs, particularly in years of high tick activity and when characteristic necrotic foci occur in spleen, liver, and lung.",
keywords = "Abortion, Diagnosis, Francisella tularensis, Immunohistochemistry, Sheep, South Dakota, Tularemia, Wood tick, Wyoming",
author = "Donal O'Toole and Williams, {Elizabeth S.} and Leslie Woods and Kenneth Mills and Amy Boerger-Fields and Montgomery, {Donald L.} and Paula Jaeger and Edwards, {William H.} and Dwayne Christensen and William Marlatt",
year = "2008",
month = "7",
day = "1",
language = "English (US)",
volume = "20",
pages = "508--513",
journal = "Journal of Veterinary Diagnostic Investigation",
issn = "1040-6387",
publisher = "American Association of Veterinary Laboratory Diagnosticians",
number = "4",

}

TY - JOUR

T1 - Tularemia in range sheep

T2 - An overlooked syndrome?

AU - O'Toole, Donal

AU - Williams, Elizabeth S.

AU - Woods, Leslie

AU - Mills, Kenneth

AU - Boerger-Fields, Amy

AU - Montgomery, Donald L.

AU - Jaeger, Paula

AU - Edwards, William H.

AU - Christensen, Dwayne

AU - Marlatt, William

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Abortion and death caused by Francisella tularensis were well recognized in range flocks of domestic sheep in Idaho, Montana, and Wyoming in the first 6 decades of the 20th century. The current report describes 4 episodes of tularemia in 3 range flocks in Wyoming and South Dakota in 1997 and 2007 (1 flock was affected twice). Flock owners reported that ticks were unusually numerous and commonly present on sheep during outbreaks. Tularemia presented as late-term abortions (3 episodes) or listlessness and death in lambs and, to a lesser extent, ewes (1 episode). Lesions were multifocal pinpoint necrotic foci in tissues, particularly spleen, liver, and lung. An immunohistochemical procedure demonstrated F. tularensis, particularly in necrotic foci. The diagnosis was corroborated by bacterial isolation and, in individual cases, by serology, fluorescent antibody assay, and/or polymerase chain reaction detection of F. tularensis. Diagnosticians in endemic areas should include tularemia as a differential diagnosis when investigating late-term abortions or outbreaks of fatal illness in young lambs, particularly in years of high tick activity and when characteristic necrotic foci occur in spleen, liver, and lung.

AB - Abortion and death caused by Francisella tularensis were well recognized in range flocks of domestic sheep in Idaho, Montana, and Wyoming in the first 6 decades of the 20th century. The current report describes 4 episodes of tularemia in 3 range flocks in Wyoming and South Dakota in 1997 and 2007 (1 flock was affected twice). Flock owners reported that ticks were unusually numerous and commonly present on sheep during outbreaks. Tularemia presented as late-term abortions (3 episodes) or listlessness and death in lambs and, to a lesser extent, ewes (1 episode). Lesions were multifocal pinpoint necrotic foci in tissues, particularly spleen, liver, and lung. An immunohistochemical procedure demonstrated F. tularensis, particularly in necrotic foci. The diagnosis was corroborated by bacterial isolation and, in individual cases, by serology, fluorescent antibody assay, and/or polymerase chain reaction detection of F. tularensis. Diagnosticians in endemic areas should include tularemia as a differential diagnosis when investigating late-term abortions or outbreaks of fatal illness in young lambs, particularly in years of high tick activity and when characteristic necrotic foci occur in spleen, liver, and lung.

KW - Abortion

KW - Diagnosis

KW - Francisella tularensis

KW - Immunohistochemistry

KW - Sheep

KW - South Dakota

KW - Tularemia

KW - Wood tick

KW - Wyoming

UR - http://www.scopus.com/inward/record.url?scp=54549084433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54549084433&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 508

EP - 513

JO - Journal of Veterinary Diagnostic Investigation

JF - Journal of Veterinary Diagnostic Investigation

SN - 1040-6387

IS - 4

ER -