Tuberculous spondylitis as a complication of intravesical bacillus Calmette-Guerin therapy

J. R. Fishman; D. T. Walton; N. M. Flynn; D. R. Benson; Ralph W deVere White

Tuberculous spondylitis as a complication of intravesical bacillus Calmette-Guerin therapy

J. R. Fishman, D. T. Walton, N. M. Flynn, D. R. Benson, Ralph W deVere White

Urology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We report a case of tuberculous spondylitis following intravesical bacillus Calmette-Guerin (BCG) instillation. A 90-year-old male physician living in South Africa received an uncomplicated 6-week course of intravesical BCG (Japanese 172 strain) for high grade superficial bladder carcinoma. He experienced a sudden onset of debilitating lower back pain 16 months following this treatment. A lytic lesion involving the anterior T11 and T12 vertebral bodies was diagnosed and subsequently biopsied. An acid- fast organism was isolated after 3 weeks of incubation and was confirmed through deoxyribonucleic acid probe hybridization as a mycobacterium. High performance liquid chromatography analysis speciated the organism as Mycobacterium bovis BCG, proving that it was acquired through the intravesical therapy.

Original language	English (US)
Pages (from-to)	584-587
Number of pages	4
Journal	Journal of Urology
Volume	149
Issue number	3
State	Published - 1993

Keywords

BCG vaccine
bladder neoplasms
tuberculosis, spinal

ASJC Scopus subject areas

Urology

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title = "Tuberculous spondylitis as a complication of intravesical bacillus Calmette-Guerin therapy",

abstract = "We report a case of tuberculous spondylitis following intravesical bacillus Calmette-Guerin (BCG) instillation. A 90-year-old male physician living in South Africa received an uncomplicated 6-week course of intravesical BCG (Japanese 172 strain) for high grade superficial bladder carcinoma. He experienced a sudden onset of debilitating lower back pain 16 months following this treatment. A lytic lesion involving the anterior T11 and T12 vertebral bodies was diagnosed and subsequently biopsied. An acid- fast organism was isolated after 3 weeks of incubation and was confirmed through deoxyribonucleic acid probe hybridization as a mycobacterium. High performance liquid chromatography analysis speciated the organism as Mycobacterium bovis BCG, proving that it was acquired through the intravesical therapy.",

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AU - Walton, D. T.

AU - Flynn, N. M.

AU - Benson, D. R.

AU - deVere White, Ralph W

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Y1 - 1993

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AB - We report a case of tuberculous spondylitis following intravesical bacillus Calmette-Guerin (BCG) instillation. A 90-year-old male physician living in South Africa received an uncomplicated 6-week course of intravesical BCG (Japanese 172 strain) for high grade superficial bladder carcinoma. He experienced a sudden onset of debilitating lower back pain 16 months following this treatment. A lytic lesion involving the anterior T11 and T12 vertebral bodies was diagnosed and subsequently biopsied. An acid- fast organism was isolated after 3 weeks of incubation and was confirmed through deoxyribonucleic acid probe hybridization as a mycobacterium. High performance liquid chromatography analysis speciated the organism as Mycobacterium bovis BCG, proving that it was acquired through the intravesical therapy.

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Tuberculous spondylitis as a complication of intravesical bacillus Calmette-Guerin therapy

Abstract

Keywords

ASJC Scopus subject areas

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