Abstract
We report a case of tuberculous spondylitis following intravesical bacillus Calmette-Guerin (BCG) instillation. A 90-year-old male physician living in South Africa received an uncomplicated 6-week course of intravesical BCG (Japanese 172 strain) for high grade superficial bladder carcinoma. He experienced a sudden onset of debilitating lower back pain 16 months following this treatment. A lytic lesion involving the anterior T11 and T12 vertebral bodies was diagnosed and subsequently biopsied. An acid- fast organism was isolated after 3 weeks of incubation and was confirmed through deoxyribonucleic acid probe hybridization as a mycobacterium. High performance liquid chromatography analysis speciated the organism as Mycobacterium bovis BCG, proving that it was acquired through the intravesical therapy.
Original language | English (US) |
---|---|
Pages (from-to) | 584-587 |
Number of pages | 4 |
Journal | Journal of Urology |
Volume | 149 |
Issue number | 3 |
State | Published - 1993 |
Keywords
- BCG vaccine
- bladder neoplasms
- tuberculosis, spinal
ASJC Scopus subject areas
- Urology