Tuberculosis transmission based on molecular epidemiologic research

Kathryn DeRiemer, Charles L. Daley

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Molecular genotyping techniques developed during the past decade and conventional epidemiological methods have been used synergistically in studies of the transmission and pathogenesis of Mycobacterium tuberculosis. Research studies assessing contacts and outbreaks, risk factors for ongoing transmission, and exogenous reinfection with M. tuberculosis have advanced with applied molecular epidemiologic techniques. In addition, molecular epidemiologic approaches have enabled scientists to assess the impact of drug resistance on the transmission and pathogenesis of M. tuberculosis and to identify strains with broad temporal and spatial distributions. In the near future, the intersection of molecular epidemiology, bacterial population genetics, comparative genomics, immunology, and other disciplines will further our understanding of tuberculosis transmission and pathogenesis, contributing to the development of effective drugs and a vaccine against this important human pathogen.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalSeminars in Respiratory and Critical Care Medicine
Volume25
Issue number3
DOIs
StatePublished - Jun 2004
Externally publishedYes

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Keywords

  • Genotyping
  • Molecular epidemiology
  • Mycobacterium tuberculosis
  • Transmission
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Critical Care

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