Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa

Kenneth S. Brandenburg, Karien J. Rodriguez, Jonathan F. McAnulty, Christopher J Murphy, Nicholas L. Abbott, Michael J. Schurr, Charles J. Czuprynski

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the D and L isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of D and L isoforms producing the greatest inhibitory effect. Addition of D-/L-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.

Original languageEnglish (US)
Pages (from-to)1921-1925
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number4
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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