Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa

Kenneth S. Brandenburg, Karien J. Rodriguez, Jonathan F. McAnulty, Christopher J Murphy, Nicholas L. Abbott, Michael J. Schurr, Charles J. Czuprynski

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the D and L isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of D and L isoforms producing the greatest inhibitory effect. Addition of D-/L-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.

Original languageEnglish (US)
Pages (from-to)1921-1925
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Biofilms
Tryptophan
Pseudomonas aeruginosa
Protein Isoforms
Pathology
Wounds and Injuries
Growth

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Brandenburg, K. S., Rodriguez, K. J., McAnulty, J. F., Murphy, C. J., Abbott, N. L., Schurr, M. J., & Czuprynski, C. J. (2013). Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 57(4), 1921-1925. https://doi.org/10.1128/AAC.00007-13

Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. / Brandenburg, Kenneth S.; Rodriguez, Karien J.; McAnulty, Jonathan F.; Murphy, Christopher J; Abbott, Nicholas L.; Schurr, Michael J.; Czuprynski, Charles J.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 4, 04.2013, p. 1921-1925.

Research output: Contribution to journalArticle

Brandenburg, KS, Rodriguez, KJ, McAnulty, JF, Murphy, CJ, Abbott, NL, Schurr, MJ & Czuprynski, CJ 2013, 'Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa', Antimicrobial Agents and Chemotherapy, vol. 57, no. 4, pp. 1921-1925. https://doi.org/10.1128/AAC.00007-13
Brandenburg KS, Rodriguez KJ, McAnulty JF, Murphy CJ, Abbott NL, Schurr MJ et al. Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2013 Apr;57(4):1921-1925. https://doi.org/10.1128/AAC.00007-13
Brandenburg, Kenneth S. ; Rodriguez, Karien J. ; McAnulty, Jonathan F. ; Murphy, Christopher J ; Abbott, Nicholas L. ; Schurr, Michael J. ; Czuprynski, Charles J. / Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 4. pp. 1921-1925.
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