TRPML1ng on sparks

Madeline Nieves-Cintron; Luis F. Santana; Manuel F Navedo

doi:10.1126/scisignal.abc0993

TRPML1ng on sparks

Madeline Nieves-Cintron, Luis F. Santana, Manuel F Navedo

Research output: Contribution to journal › Review article › peer-review

Abstract

In this issue of Science Signaling, Thakore et al. report that the Ca2+-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca2+ sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.

Original language	English (US)
Journal	Science Signaling
Volume	13
Issue number	637
DOIs	https://doi.org/10.1126/scisignal.abc0993
State	Published - Jun 23 2020

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1126/scisignal.abc0993

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title = "TRPML1ng on sparks",

abstract = "In this issue of Science Signaling, Thakore et al. report that the Ca2+-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca2+ sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.",

author = "Madeline Nieves-Cintron and Santana, {Luis F.} and Navedo, {Manuel F}",

year = "2020",

month = jun,

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doi = "10.1126/scisignal.abc0993",

language = "English (US)",

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publisher = "American Association for the Advancement of Science",

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AU - Nieves-Cintron, Madeline

AU - Santana, Luis F.

AU - Navedo, Manuel F

PY - 2020/6/23

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N2 - In this issue of Science Signaling, Thakore et al. report that the Ca2+-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca2+ sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.

AB - In this issue of Science Signaling, Thakore et al. report that the Ca2+-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca2+ sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.

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DO - 10.1126/scisignal.abc0993

M3 - Review article

C2 - 32576679

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JO - Science's STKE : signal transduction knowledge environment

JF - Science's STKE : signal transduction knowledge environment

SN - 1937-9145

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TRPML1ng on sparks

Abstract

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