TRP Channels in Cardiovascular Disease

Kavisha Singh, Nancy Luo, Paul Rosenberg

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transient receptor potential (TRP) channels comprise a large superfamily of channels activated under conditions associated with cellular stress including stretch, neurohormonal signaling, hypoxia, and oxidative stress. Although often considered to be operative in nonexcitable cells, emerging data suggests that these channels are critically important to the function of cells in the heart and vasculature. Dysregulation of these channels during cardiac stress contributes to the maladaptive response during cardiac disease. Here, we consider the role of the TRP channels in cardiac failure, arrhythmogenesis, and pulmonary arterial hypertension. We discuss the importance of specific channels, the signaling cascades activated by TRP channels, and potential therapeutic agents. Thus, the case is building that selective and specific antagonism of TRP channels will become an important goal.

Original languageEnglish (US)
Title of host publicationTRP Channels as Therapeutic Targets
Subtitle of host publicationFrom Basic Science to Clinical Use
PublisherElsevier Inc.
Pages365-383
Number of pages19
ISBN (Electronic)9780124200791
ISBN (Print)9780124200241
DOIs
StatePublished - Apr 8 2015
Externally publishedYes

Fingerprint

Transient Receptor Potential Channels
Cardiovascular Diseases
Disease
antagonism
hypertension
Pulmonary Hypertension
Heart Diseases
Oxidative Stress
Heart Failure

Keywords

  • Arrhythmogenesis
  • Cardiac conduction
  • Cardiac hypertrophy and failure
  • Pulmonary hypertension
  • TRP channels

ASJC Scopus subject areas

  • Medicine(all)
  • Social Sciences(all)

Cite this

Singh, K., Luo, N., & Rosenberg, P. (2015). TRP Channels in Cardiovascular Disease. In TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use (pp. 365-383). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-420024-1.00020-5

TRP Channels in Cardiovascular Disease. / Singh, Kavisha; Luo, Nancy; Rosenberg, Paul.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Elsevier Inc., 2015. p. 365-383.

Research output: Chapter in Book/Report/Conference proceedingChapter

Singh, K, Luo, N & Rosenberg, P 2015, TRP Channels in Cardiovascular Disease. in TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Elsevier Inc., pp. 365-383. https://doi.org/10.1016/B978-0-12-420024-1.00020-5
Singh K, Luo N, Rosenberg P. TRP Channels in Cardiovascular Disease. In TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Elsevier Inc. 2015. p. 365-383 https://doi.org/10.1016/B978-0-12-420024-1.00020-5
Singh, Kavisha ; Luo, Nancy ; Rosenberg, Paul. / TRP Channels in Cardiovascular Disease. TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Elsevier Inc., 2015. pp. 365-383
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