TRP Channels in Cardiovascular Disease

Kavisha Singh, Nancy Luo, Paul Rosenberg

Research output: Chapter in Book/Report/Conference proceedingChapter


Transient receptor potential (TRP) channels comprise a large superfamily of channels activated under conditions associated with cellular stress including stretch, neurohormonal signaling, hypoxia, and oxidative stress. Although often considered to be operative in nonexcitable cells, emerging data suggests that these channels are critically important to the function of cells in the heart and vasculature. Dysregulation of these channels during cardiac stress contributes to the maladaptive response during cardiac disease. Here, we consider the role of the TRP channels in cardiac failure, arrhythmogenesis, and pulmonary arterial hypertension. We discuss the importance of specific channels, the signaling cascades activated by TRP channels, and potential therapeutic agents. Thus, the case is building that selective and specific antagonism of TRP channels will become an important goal.

Original languageEnglish (US)
Title of host publicationTRP Channels as Therapeutic Targets
Subtitle of host publicationFrom Basic Science to Clinical Use
PublisherElsevier Inc.
Number of pages19
ISBN (Electronic)9780124200791
ISBN (Print)9780124200241
StatePublished - Apr 8 2015
Externally publishedYes


  • Arrhythmogenesis
  • Cardiac conduction
  • Cardiac hypertrophy and failure
  • Pulmonary hypertension
  • TRP channels

ASJC Scopus subject areas

  • Medicine(all)
  • Social Sciences(all)


Dive into the research topics of 'TRP Channels in Cardiovascular Disease'. Together they form a unique fingerprint.

Cite this