Triple asymmetric synthesis for fragment assembly: Validity of approximate multiplicativity of the three diastereofacial selectivities

Allen J. Duplantier, Michael H. Nantz, John C. Roberts, Robert P. Short, Peter Somfai, Satoru Masamune

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

A strategy of triple asymmetric synthesis is illustrated to be effective for stereochemical control in fragment assembly, a task often encountered in convergent natural product synthesis. The stereochemical outcome of aldol reactions involving three chiral components supports a rule of approximate multiplicativity of facial selectivities intrinsic to the chiral reactants involved in each reaction.

Original languageEnglish (US)
Pages (from-to)7357-7360
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number52
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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