Abstract
Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1230-1232 |
| Number of pages | 3 |
| Journal | South African Medical Journal |
| Volume | 47 |
| Issue number | 29 |
| State | Published - 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Trimethoprim sulphamethoxazole therapy and folate nutrition. / Spector, I.; Green, Ralph; Bowes, D.; Cohen, H.; Miller, S.; Metz, J.
In: South African Medical Journal, Vol. 47, No. 29, 1973, p. 1230-1232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trimethoprim sulphamethoxazole therapy and folate nutrition
AU - Spector, I.
AU - Green, Ralph
AU - Bowes, D.
AU - Cohen, H.
AU - Miller, S.
AU - Metz, J.
PY - 1973
Y1 - 1973
N2 - Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.
AB - Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015833338&partnerID=8YFLogxK
M3 - Article
VL - 47
SP - 1230
EP - 1232
JO - South African Medical Journal
JF - South African Medical Journal
SN - 0038-2469
IS - 29
ER -