Trimethoprim sulphamethoxazole therapy and folate nutrition

I. Spector, Ralph Green, D. Bowes, H. Cohen, S. Miller, J. Metz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.

Original languageEnglish (US)
Pages (from-to)1230-1232
Number of pages3
JournalSouth African Medical Journal
Volume47
Issue number29
StatePublished - 1973
Externally publishedYes

Fingerprint

Nutrition Therapy
Sulfamethoxazole
Trimethoprim
Folic Acid
Hematologic Tests
Drug Combinations
Platelet Count
Hemoglobins
Therapeutics
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spector, I., Green, R., Bowes, D., Cohen, H., Miller, S., & Metz, J. (1973). Trimethoprim sulphamethoxazole therapy and folate nutrition. South African Medical Journal, 47(29), 1230-1232.

Trimethoprim sulphamethoxazole therapy and folate nutrition. / Spector, I.; Green, Ralph; Bowes, D.; Cohen, H.; Miller, S.; Metz, J.

In: South African Medical Journal, Vol. 47, No. 29, 1973, p. 1230-1232.

Research output: Contribution to journalArticle

Spector, I, Green, R, Bowes, D, Cohen, H, Miller, S & Metz, J 1973, 'Trimethoprim sulphamethoxazole therapy and folate nutrition', South African Medical Journal, vol. 47, no. 29, pp. 1230-1232.
Spector I, Green R, Bowes D, Cohen H, Miller S, Metz J. Trimethoprim sulphamethoxazole therapy and folate nutrition. South African Medical Journal. 1973;47(29):1230-1232.
Spector, I. ; Green, Ralph ; Bowes, D. ; Cohen, H. ; Miller, S. ; Metz, J. / Trimethoprim sulphamethoxazole therapy and folate nutrition. In: South African Medical Journal. 1973 ; Vol. 47, No. 29. pp. 1230-1232.
@article{301aa398d00143a4be37f1f555bca4a7,
title = "Trimethoprim sulphamethoxazole therapy and folate nutrition",
abstract = "Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.",
author = "I. Spector and Ralph Green and D. Bowes and H. Cohen and S. Miller and J. Metz",
year = "1973",
language = "English (US)",
volume = "47",
pages = "1230--1232",
journal = "South African Medical Journal",
issn = "0038-2469",
publisher = "South African Medical Association",
number = "29",

}

TY - JOUR

T1 - Trimethoprim sulphamethoxazole therapy and folate nutrition

AU - Spector, I.

AU - Green, Ralph

AU - Bowes, D.

AU - Cohen, H.

AU - Miller, S.

AU - Metz, J.

PY - 1973

Y1 - 1973

N2 - Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.

AB - Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.

UR - http://www.scopus.com/inward/record.url?scp=0015833338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015833338&partnerID=8YFLogxK

M3 - Article

VL - 47

SP - 1230

EP - 1232

JO - South African Medical Journal

JF - South African Medical Journal

SN - 0038-2469

IS - 29

ER -