Trimethoprim sulphamethoxazole therapy and folate nutrition

I. Spector, Ralph Green, D. Bowes, H. Cohen, S. Miller, J. Metz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.

Original languageEnglish (US)
Pages (from-to)1230-1232
Number of pages3
JournalSouth African Medical Journal
Issue number29
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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