Treatment of infection with the drug combination of trimethoprim sulphamethoxazole (TMP S) in the recommended dose did not result in adverse haematological effects in patients with normal folate nutrition. TMP S given to patients with suboptimal folate stores sometimes resulted in the appearance or aggravation of both morphological and biochemical indices of folate depletion, although over a period of 10 days there were no significant alterations in the haemoglobin levels or platelet counts. It is suggested that if treatment with TMP S in 'at risk' patients is necessary over prolonged periods, then haematological indices and tests of folate status should be checked at regular intervals.
|Original language||English (US)|
|Number of pages||3|
|Journal||South African Medical Journal|
|State||Published - 1973|
ASJC Scopus subject areas