Triglycerides Are Negatively Correlated With Cognitive Function in Nondemented Aging Adults

Vishnu Parthasarathy, Darvis T. Frazier, Brianne M. Bettcher, Laura Jastrzab, Linda Chao, Bruce R Reed, Dan M Mungas, Michael Weiner, Charles DeCarli, Helena Chui, Joel H. Kramer

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Vascular risk factors like hyperlipidemia may adversely affect brain function. We hypothesized that increased serum triglycerides are associated with decreased executive function and memory in nondemented elderly subjects. We also researched possible vascular mediators and white matter microstructure as assessed with diffusion tensor imaging (DTI). Design/Method: Participants were 251 nondemented elderly adults (54% male) with a mean age of 78 (SD = 6.4; range: 62-94) years and a mean education of 15.6 (SD = 2.9; range: 8-23) years. Fasting blood samples were used to detect serum triglyceride and low-density lipoprotein (LDL) levels along with ApoE4 status. DTI was used to determine whole brain fractional anisotropy (FA). Composite executive and memory scores were derived from item response theory. Clinical Dementia Rating (CDR) scores provided informant-based measures of daily functioning. Results: Triglyceride levels were inversely correlated with executive function, but there was no relationship with memory. Controlling for age, gender, and education did not affect this correlation. This relationship persisted after controlling for vascular risk factors like LDL, total cholesterol, CDR and ApoE4 status. Lastly, adding whole-brain FA to the model did not affect the correlation between triglycerides and executive function. Conclusion: Triglyceride levels are inversely correlated with executive function in nondemented elderly adults after controlling for age, education, gender, total cholesterol, LDL, ApoE4 status, CDR, and white-matter microstructure. The fact that the effect of triglycerides on cognition was not clearly mediated by vascular risks or cerebrovascular injury raises questions about widely held assumptions of how triglycerides might impact cognition function. (PsycINFO Database Record

Original languageEnglish (US)
JournalNeuropsychology
DOIs
StateAccepted/In press - Jun 12 2017

Fingerprint

Cognition
Triglycerides
Executive Function
Apolipoprotein E4
Dementia
Diffusion Tensor Imaging
Anisotropy
Education
LDL Cholesterol
Blood Vessels
Brain
Hyperlipidemias
Serum
Cognitive Function
Fasting
Rating
Wounds and Injuries
Microstructure
Imaging
Cholesterol

Keywords

  • Aging
  • Dementia
  • Executive function
  • Memory
  • Triglycerides

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Parthasarathy, V., Frazier, D. T., Bettcher, B. M., Jastrzab, L., Chao, L., Reed, B. R., ... Kramer, J. H. (Accepted/In press). Triglycerides Are Negatively Correlated With Cognitive Function in Nondemented Aging Adults. Neuropsychology. https://doi.org/10.1037/neu0000335

Triglycerides Are Negatively Correlated With Cognitive Function in Nondemented Aging Adults. / Parthasarathy, Vishnu; Frazier, Darvis T.; Bettcher, Brianne M.; Jastrzab, Laura; Chao, Linda; Reed, Bruce R; Mungas, Dan M; Weiner, Michael; DeCarli, Charles; Chui, Helena; Kramer, Joel H.

In: Neuropsychology, 12.06.2017.

Research output: Contribution to journalArticle

Parthasarathy, Vishnu ; Frazier, Darvis T. ; Bettcher, Brianne M. ; Jastrzab, Laura ; Chao, Linda ; Reed, Bruce R ; Mungas, Dan M ; Weiner, Michael ; DeCarli, Charles ; Chui, Helena ; Kramer, Joel H. / Triglycerides Are Negatively Correlated With Cognitive Function in Nondemented Aging Adults. In: Neuropsychology. 2017.
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abstract = "Objective: Vascular risk factors like hyperlipidemia may adversely affect brain function. We hypothesized that increased serum triglycerides are associated with decreased executive function and memory in nondemented elderly subjects. We also researched possible vascular mediators and white matter microstructure as assessed with diffusion tensor imaging (DTI). Design/Method: Participants were 251 nondemented elderly adults (54{\%} male) with a mean age of 78 (SD = 6.4; range: 62-94) years and a mean education of 15.6 (SD = 2.9; range: 8-23) years. Fasting blood samples were used to detect serum triglyceride and low-density lipoprotein (LDL) levels along with ApoE4 status. DTI was used to determine whole brain fractional anisotropy (FA). Composite executive and memory scores were derived from item response theory. Clinical Dementia Rating (CDR) scores provided informant-based measures of daily functioning. Results: Triglyceride levels were inversely correlated with executive function, but there was no relationship with memory. Controlling for age, gender, and education did not affect this correlation. This relationship persisted after controlling for vascular risk factors like LDL, total cholesterol, CDR and ApoE4 status. Lastly, adding whole-brain FA to the model did not affect the correlation between triglycerides and executive function. Conclusion: Triglyceride levels are inversely correlated with executive function in nondemented elderly adults after controlling for age, education, gender, total cholesterol, LDL, ApoE4 status, CDR, and white-matter microstructure. The fact that the effect of triglycerides on cognition was not clearly mediated by vascular risks or cerebrovascular injury raises questions about widely held assumptions of how triglycerides might impact cognition function. (PsycINFO Database Record",
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AU - Chao, Linda

AU - Reed, Bruce R

AU - Mungas, Dan M

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AB - Objective: Vascular risk factors like hyperlipidemia may adversely affect brain function. We hypothesized that increased serum triglycerides are associated with decreased executive function and memory in nondemented elderly subjects. We also researched possible vascular mediators and white matter microstructure as assessed with diffusion tensor imaging (DTI). Design/Method: Participants were 251 nondemented elderly adults (54% male) with a mean age of 78 (SD = 6.4; range: 62-94) years and a mean education of 15.6 (SD = 2.9; range: 8-23) years. Fasting blood samples were used to detect serum triglyceride and low-density lipoprotein (LDL) levels along with ApoE4 status. DTI was used to determine whole brain fractional anisotropy (FA). Composite executive and memory scores were derived from item response theory. Clinical Dementia Rating (CDR) scores provided informant-based measures of daily functioning. Results: Triglyceride levels were inversely correlated with executive function, but there was no relationship with memory. Controlling for age, gender, and education did not affect this correlation. This relationship persisted after controlling for vascular risk factors like LDL, total cholesterol, CDR and ApoE4 status. Lastly, adding whole-brain FA to the model did not affect the correlation between triglycerides and executive function. Conclusion: Triglyceride levels are inversely correlated with executive function in nondemented elderly adults after controlling for age, education, gender, total cholesterol, LDL, ApoE4 status, CDR, and white-matter microstructure. The fact that the effect of triglycerides on cognition was not clearly mediated by vascular risks or cerebrovascular injury raises questions about widely held assumptions of how triglycerides might impact cognition function. (PsycINFO Database Record

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