Abstract
Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 914-922 |
| Number of pages | 9 |
| Journal | Journal of Lipid Research |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2004 |
| Externally published | Yes |
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Keywords
- Fish
- N-3 polyunsaturated fatty acid
- Stearoyl coenzyme A
ASJC Scopus subject areas
- Endocrinology
Cite this
Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. / Shiwaku, Kuninori; Hashimoto, Michio; Kitajima, Keiko; Nogi, Akiko; Erdembileg, Anuurad; Byambaa, Enkhmaa; Kim, Jung Man; Kim, In Shik; Lee, Sung Kook; Oyunsuren, Tsendsuren; Shido, Osamu; Yamane, Yosuke.
In: Journal of Lipid Research, Vol. 45, No. 5, 05.2004, p. 914-922.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians
AU - Shiwaku, Kuninori
AU - Hashimoto, Michio
AU - Kitajima, Keiko
AU - Nogi, Akiko
AU - Erdembileg, Anuurad
AU - Byambaa, Enkhmaa
AU - Kim, Jung Man
AU - Kim, In Shik
AU - Lee, Sung Kook
AU - Oyunsuren, Tsendsuren
AU - Shido, Osamu
AU - Yamane, Yosuke
PY - 2004/5
Y1 - 2004/5
N2 - Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.
AB - Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.
KW - Fish
KW - N-3 polyunsaturated fatty acid
KW - Stearoyl coenzyme A
UR - http://www.scopus.com/inward/record.url?scp=11144357407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144357407&partnerID=8YFLogxK
U2 - 10.1194/jlr.M300483-JLR200
DO - 10.1194/jlr.M300483-JLR200
M3 - Article
C2 - 14967817
AN - SCOPUS:11144357407
VL - 45
SP - 914
EP - 922
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 5
ER -