Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians

Kuninori Shiwaku, Michio Hashimoto, Keiko Kitajima, Akiko Nogi, Anuurad Erdembileg, Enkhmaa Byambaa, Jung Man Kim, In Shik Kim, Sung Kook Lee, Tsendsuren Oyunsuren, Osamu Shido, Yosuke Yamane

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.

Original languageEnglish (US)
Pages (from-to)914-922
Number of pages9
JournalJournal of Lipid Research
Volume45
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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Stearoyl-CoA Desaturase
Omega-3 Fatty Acids
Triglycerides
Plasmas
Hypertriglyceridemia
Oleic Acid
Nutrition
Regression analysis
Fish
Fishes
Body Mass Index
Cardiovascular Diseases
Regression Analysis
Carbohydrates
Diet
Incidence

Keywords

  • Fish
  • N-3 polyunsaturated fatty acid
  • Stearoyl coenzyme A

ASJC Scopus subject areas

  • Endocrinology

Cite this

Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. / Shiwaku, Kuninori; Hashimoto, Michio; Kitajima, Keiko; Nogi, Akiko; Erdembileg, Anuurad; Byambaa, Enkhmaa; Kim, Jung Man; Kim, In Shik; Lee, Sung Kook; Oyunsuren, Tsendsuren; Shido, Osamu; Yamane, Yosuke.

In: Journal of Lipid Research, Vol. 45, No. 5, 05.2004, p. 914-922.

Research output: Contribution to journalArticle

Shiwaku, Kuninori ; Hashimoto, Michio ; Kitajima, Keiko ; Nogi, Akiko ; Erdembileg, Anuurad ; Byambaa, Enkhmaa ; Kim, Jung Man ; Kim, In Shik ; Lee, Sung Kook ; Oyunsuren, Tsendsuren ; Shido, Osamu ; Yamane, Yosuke. / Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. In: Journal of Lipid Research. 2004 ; Vol. 45, No. 5. pp. 914-922.
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AU - Shiwaku, Kuninori

AU - Hashimoto, Michio

AU - Kitajima, Keiko

AU - Nogi, Akiko

AU - Erdembileg, Anuurad

AU - Byambaa, Enkhmaa

AU - Kim, Jung Man

AU - Kim, In Shik

AU - Lee, Sung Kook

AU - Oyunsuren, Tsendsuren

AU - Shido, Osamu

AU - Yamane, Yosuke

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N2 - Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.

AB - Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The hypotriglyceridemic effects of n-3 PUFAs have been confirmed in Caucasians, but the effect in Asians is less clear. Recent evidence indicates that stearoyl-CoA desaturase (SCD) activity induced with high-carbohydrate diets increases plasma triglyceride levels. We investigated the relationship between triglyceride levels and the ratio of plasma oleic acid to stearic acid (the 18:1/18:0 ratio), a plasma marker of SCD activity, and n-3 PUFAs in 411 Japanese, 418 Korean, and 251 Mongolian adults. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower body mass index values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkably higher values for n-3 PUFAs than did the Mongolians. Multiple regression analysis showed that triglyceride levels had a great magnitude of correlation with the increases in 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFAs remained significant for the Mongolians. HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians.

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