Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase

Katsuyuki Nakajima, Yoshiharu Tokita, Koji Sakamaki, Younosuke Shimomura, Junji Kobayashi, Keiko Kamachi, Akira Tanaka, Kimber Stanhope, Peter J Havel, Tao Wang, Tetsuo Machida, Masami Murakami

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma. Methods TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal. Results RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal. Conclusions Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalClinica Chimica Acta
Volume465
DOIs
StatePublished - Feb 1 2017

Keywords

  • Fasting and postprandial plasma
  • Food intake (fat load)
  • Hepatic triglyceride lipase (HTGL)
  • Lipoprotein lipase (LPL)
  • Remnant lipoproteins (RLP)
  • RLP-C
  • RLP-TG
  • Triglycerides (TG)

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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