TY - JOUR
T1 - Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase
AU - Nakajima, Katsuyuki
AU - Tokita, Yoshiharu
AU - Sakamaki, Koji
AU - Shimomura, Younosuke
AU - Kobayashi, Junji
AU - Kamachi, Keiko
AU - Tanaka, Akira
AU - Stanhope, Kimber L.
AU - Havel, Peter J.
AU - Wang, Tao
AU - Machida, Tetsuo
AU - Murakami, Masami
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma. Methods TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal. Results RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal. Conclusions Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
AB - Background Previous large population studies reported that non-fasting plasma triglyceride (TG) reflect a higher risk for cardiovascular disease than TG in the fasting plasma. This is suggestive of the presence of higher concentration of remnant lipoproteins (RLP) in postprandial plasma. Methods TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal. Results RLP-TG/TG ratio (concentration) and RLP-TG/RLP-C ratio (particle size) were significantly increased in the postprandial plasma of both healthy controls and CAD patients compared with those in fasting plasma. LPL/RLP-TG ratio demonstrated the interaction correlation between RLP concentration and LPL activity The increased RLP-TG after fat consumption contributed to approximately 90% of the increased plasma TG, while approximately 60% after a typical meal. Plasma LPL in postprandial plasma was not significantly altered after either type of meal. Conclusions Concentrations of RLP-TG found in the TG along with its particle size are significantly increased in postprandial plasma compared with fasting plasma. Therefore, non-fasting TG determination better reflects the presence of higher RLP concentrations in plasma.
KW - Fasting and postprandial plasma
KW - Food intake (fat load)
KW - Hepatic triglyceride lipase (HTGL)
KW - Lipoprotein lipase (LPL)
KW - Remnant lipoproteins (RLP)
KW - RLP-C
KW - RLP-TG
KW - Triglycerides (TG)
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U2 - 10.1016/j.cca.2016.12.011
DO - 10.1016/j.cca.2016.12.011
M3 - Article
C2 - 27986550
AN - SCOPUS:85006455472
VL - 465
SP - 45
EP - 52
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
ER -