Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.

Mark J. Kurth, Larry A. Milco, R. Bryan Miller

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.

Original languageEnglish (US)
Pages (from-to)1407-1416
Number of pages10
JournalTetrahedron
Volume48
Issue number8
DOIs
StatePublished - Feb 21 1992

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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