Abstract
We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.
Original language | English (US) |
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Pages (from-to) | 1407-1416 |
Number of pages | 10 |
Journal | Tetrahedron |
Volume | 48 |
Issue number | 8 |
DOIs | |
State | Published - Feb 21 1992 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery