Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.

Mark J. Kurth; Larry A. Milco; R. Bryan Miller

doi:10.1016/S0040-4020(01)92230-6

Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.

Mark J. Kurth, Larry A. Milco, R. Bryan Miller

Chemistry

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.

Original language	English (US)
Pages (from-to)	1407-1416
Number of pages	10
Journal	Tetrahedron
Volume	48
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(01)92230-6
State	Published - Feb 21 1992

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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Kurth, M. J., Milco, L. A., & Bryan Miller, R. (1992). Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues. Tetrahedron, 48(8), 1407-1416. https://doi.org/10.1016/S0040-4020(01)92230-6

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abstract = "We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.",

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