Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.

Mark J. Kurth; Larry A. Milco; R. Bryan Miller

doi:10.1016/S0040-4020(01)92230-6

Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.

Mark J. Kurth, Larry A. Milco, R. Bryan Miller

Chemistry

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6 Scopus citations

Abstract

We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.

Original language	English (US)
Pages (from-to)	1407-1416
Number of pages	10
Journal	Tetrahedron
Volume	48
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(01)92230-6
State	Published - Feb 21 1992

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/S0040-4020(01)92230-6

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title = "Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.",

abstract = "We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.",

author = "Kurth, {Mark J.} and Milco, {Larry A.} and {Bryan Miller}, R.",

year = "1992",

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T1 - Trifunctional reagents for substrate-protein conjugation

T2 - application to pyrrolizidine alkaloid analogues.

AU - Kurth, Mark J.

AU - Milco, Larry A.

AU - Bryan Miller, R.

PY - 1992/2/21

Y1 - 1992/2/21

N2 - We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.

AB - We report the syntheses of two pyrrolizidine alkaloid (PA) analogues (1 and 2) which exploit the novel substrate-protein coupling reagents 4 and 5. Analogues 1 and 2 incorporate the targeted PA substructural unit (i.e., a macrocyclic diester of retronecine), posses a handle for protein conjugation, and potentially maintain the conformational integrity of macrocyclic PAs.

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U2 - 10.1016/S0040-4020(01)92230-6

DO - 10.1016/S0040-4020(01)92230-6

M3 - Article

AN - SCOPUS:0026537611

VL - 48

SP - 1407

EP - 1416

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 8

ER -

Trifunctional reagents for substrate-protein conjugation: application to pyrrolizidine alkaloid analogues.

Abstract

ASJC Scopus subject areas

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