Triethyltin sulfate induced neuropathy in rats. Electrophysiologic, morphologic, and biochemical studies

D. I. Graham, P. V. De Jesus, David E Pleasure, N. K. Gonatas

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Adult rats given high orally administered doses of triethyltin (TET) sulfate lost weight, developed hind limb wasting, and became paraplegic or quadriplegic within three weeks of intoxication. A 33% reduction in the motor nerve conduction velocity (MNCV) of the sciatic nerve in the absence of significant demyelination was observed. There was observed, however, intramyelinic edema formation and an increased number of axonal neurofilaments and neurotubules; changes that paralleled the decrease in MNCV during the period of intoxication. Although the animals became asymptomatic and the MNCV normalized within two to three weeks of discontinuing the TET intoxication, the intramyelinic vacuoles and the increased numbers of neurofilaments and neurotubules persisted.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalArchives of Neurology
Volume33
Issue number1
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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