Triennial lactation symposium: Prolactin: The multifaceted potentiator of mammary growth and function

J. F. Trott, A. Schennink, W. K. Petrie, R. Manjarin, M. K. van Klompenberg, R. C. Hovey

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

At face value there are clear and established roles for prolactin (PRL) in the regulation of mammary gland growth, lactogenesis, and galactopoiesis. These actions of PRL do not occur in isolation; rather, they are finely attuned to and coordinated with many local, reproductive, and metabolic events in the female. Hence, to understand PRL action at the level of the mammary gland is to understand the systemic and local contexts in which it acts and functions. Herein we review the functions of PRL, its receptors, and the pathways leading to the phenotypes it evokes within the mammary glands, including growth and lactation, across a variety of species. At one level, the actions of PRL are mediated by several PRL receptor (PRLR) isoforms, including its long form and various short PRLR variants that are generated by alternative splicing in a species- and tissue-dependent manner. In turn, these PRLR activate a variety of intracellular signaling cascades. We also focus on how PRL coordinates with other endocrine cues to impart its effects on the mammary glands, where the ovarian hormones can independently and substantially modulate PRL action. Many of these effects of PRL are also realized at the local level of the mammary gland, either through the autocrine or paracrine synthesis of a multitude of molecules and transcription factors or through its effects on adjacent supporting tissues, including the mammary vasculature. Taken together, it is clear that PRL directs a variety of mechanisms during growth and function of the mammary gland and is deserving of its classification as the master hormone.

Original languageEnglish (US)
Pages (from-to)1674-1686
Number of pages13
JournalJournal of Animal Science
Volume90
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

prolactin
Lactation
Prolactin
breasts
Breast
Human Mammary Glands
lactation
Prolactin Receptors
mammary glands
Growth
mammary gland function
hormones
Hormones
milk synthesis
receptors
alternative splicing
Alternative Splicing
Cues
Protein Isoforms
Transcription Factors

Keywords

  • Angiogenesis
  • Estrogen
  • Lactation
  • Mammary gland
  • Progesterone
  • Prolactin

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • Genetics

Cite this

Trott, J. F., Schennink, A., Petrie, W. K., Manjarin, R., van Klompenberg, M. K., & Hovey, R. C. (2012). Triennial lactation symposium: Prolactin: The multifaceted potentiator of mammary growth and function. Journal of Animal Science, 90(5), 1674-1686. https://doi.org/10.2527/jas.2011-4682

Triennial lactation symposium : Prolactin: The multifaceted potentiator of mammary growth and function. / Trott, J. F.; Schennink, A.; Petrie, W. K.; Manjarin, R.; van Klompenberg, M. K.; Hovey, R. C.

In: Journal of Animal Science, Vol. 90, No. 5, 05.2012, p. 1674-1686.

Research output: Contribution to journalArticle

Trott, JF, Schennink, A, Petrie, WK, Manjarin, R, van Klompenberg, MK & Hovey, RC 2012, 'Triennial lactation symposium: Prolactin: The multifaceted potentiator of mammary growth and function', Journal of Animal Science, vol. 90, no. 5, pp. 1674-1686. https://doi.org/10.2527/jas.2011-4682
Trott, J. F. ; Schennink, A. ; Petrie, W. K. ; Manjarin, R. ; van Klompenberg, M. K. ; Hovey, R. C. / Triennial lactation symposium : Prolactin: The multifaceted potentiator of mammary growth and function. In: Journal of Animal Science. 2012 ; Vol. 90, No. 5. pp. 1674-1686.
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