Triclocarban enhances testosterone action

A new type of endocrine disruptor?

Jiangang Chen, Chang Ahn Ki, Nancy A. Gee, Mohamed I. Ahmed, Antoni J. Duleba, Ling Zhao, Shirley J. Gee, Bruce D. Hammock, Bill L. Lasley

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Many xenobiotics have been associated with endocrine effects in a wide range of biological systems. These associations are usually between small nonsteroid molecules and steroid receptor signaling systems. In this report, triclocarban (TCC; 3,4,4′-trichlorocarbanilide), a common ingredient in personal care products that is used as an antimicrobial agent was evaluated and found to represent a new category of endocrine-disrupting substance. A cell-based androgen receptor-mediated bioassay was used to demonstrate that TCC and other urea compounds with a similar structure, which have little or no endocrine activity when tested alone, act to enhance testosterone (T)-induced androgen receptor-mediated transcriptional activity in vitro. This amplification effect of TCC was also apparent in vivo when 0.25% TCC was added to the diet of castrated male rats that were supported by exogenous testosterone treatment for 10 d. All male sex accessory organs increased significantly in size after the T+TCC treatment, compared with T or TCC treatments alone. The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC.

Original languageEnglish (US)
Pages (from-to)1173-1179
Number of pages7
JournalEndocrinology
Volume149
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

Endocrine Disruptors
Androgen Receptors
Testosterone
Male Genitalia
Steroid Receptors
Xenobiotics
Anti-Infective Agents
Biological Assay
Urea
Hormones
Diet
triclocarban
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Chen, J., Ki, C. A., Gee, N. A., Ahmed, M. I., Duleba, A. J., Zhao, L., ... Lasley, B. L. (2008). Triclocarban enhances testosterone action: A new type of endocrine disruptor? Endocrinology, 149(3), 1173-1179. https://doi.org/10.1210/en.2007-1057

Triclocarban enhances testosterone action : A new type of endocrine disruptor? / Chen, Jiangang; Ki, Chang Ahn; Gee, Nancy A.; Ahmed, Mohamed I.; Duleba, Antoni J.; Zhao, Ling; Gee, Shirley J.; Hammock, Bruce D.; Lasley, Bill L.

In: Endocrinology, Vol. 149, No. 3, 03.2008, p. 1173-1179.

Research output: Contribution to journalArticle

Chen, J, Ki, CA, Gee, NA, Ahmed, MI, Duleba, AJ, Zhao, L, Gee, SJ, Hammock, BD & Lasley, BL 2008, 'Triclocarban enhances testosterone action: A new type of endocrine disruptor?', Endocrinology, vol. 149, no. 3, pp. 1173-1179. https://doi.org/10.1210/en.2007-1057
Chen J, Ki CA, Gee NA, Ahmed MI, Duleba AJ, Zhao L et al. Triclocarban enhances testosterone action: A new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-1179. https://doi.org/10.1210/en.2007-1057
Chen, Jiangang ; Ki, Chang Ahn ; Gee, Nancy A. ; Ahmed, Mohamed I. ; Duleba, Antoni J. ; Zhao, Ling ; Gee, Shirley J. ; Hammock, Bruce D. ; Lasley, Bill L. / Triclocarban enhances testosterone action : A new type of endocrine disruptor?. In: Endocrinology. 2008 ; Vol. 149, No. 3. pp. 1173-1179.
@article{3af529ad7eab496d9084f92698d044d8,
title = "Triclocarban enhances testosterone action: A new type of endocrine disruptor?",
abstract = "Many xenobiotics have been associated with endocrine effects in a wide range of biological systems. These associations are usually between small nonsteroid molecules and steroid receptor signaling systems. In this report, triclocarban (TCC; 3,4,4′-trichlorocarbanilide), a common ingredient in personal care products that is used as an antimicrobial agent was evaluated and found to represent a new category of endocrine-disrupting substance. A cell-based androgen receptor-mediated bioassay was used to demonstrate that TCC and other urea compounds with a similar structure, which have little or no endocrine activity when tested alone, act to enhance testosterone (T)-induced androgen receptor-mediated transcriptional activity in vitro. This amplification effect of TCC was also apparent in vivo when 0.25{\%} TCC was added to the diet of castrated male rats that were supported by exogenous testosterone treatment for 10 d. All male sex accessory organs increased significantly in size after the T+TCC treatment, compared with T or TCC treatments alone. The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC.",
author = "Jiangang Chen and Ki, {Chang Ahn} and Gee, {Nancy A.} and Ahmed, {Mohamed I.} and Duleba, {Antoni J.} and Ling Zhao and Gee, {Shirley J.} and Hammock, {Bruce D.} and Lasley, {Bill L.}",
year = "2008",
month = "3",
doi = "10.1210/en.2007-1057",
language = "English (US)",
volume = "149",
pages = "1173--1179",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Triclocarban enhances testosterone action

T2 - A new type of endocrine disruptor?

AU - Chen, Jiangang

AU - Ki, Chang Ahn

AU - Gee, Nancy A.

AU - Ahmed, Mohamed I.

AU - Duleba, Antoni J.

AU - Zhao, Ling

AU - Gee, Shirley J.

AU - Hammock, Bruce D.

AU - Lasley, Bill L.

PY - 2008/3

Y1 - 2008/3

N2 - Many xenobiotics have been associated with endocrine effects in a wide range of biological systems. These associations are usually between small nonsteroid molecules and steroid receptor signaling systems. In this report, triclocarban (TCC; 3,4,4′-trichlorocarbanilide), a common ingredient in personal care products that is used as an antimicrobial agent was evaluated and found to represent a new category of endocrine-disrupting substance. A cell-based androgen receptor-mediated bioassay was used to demonstrate that TCC and other urea compounds with a similar structure, which have little or no endocrine activity when tested alone, act to enhance testosterone (T)-induced androgen receptor-mediated transcriptional activity in vitro. This amplification effect of TCC was also apparent in vivo when 0.25% TCC was added to the diet of castrated male rats that were supported by exogenous testosterone treatment for 10 d. All male sex accessory organs increased significantly in size after the T+TCC treatment, compared with T or TCC treatments alone. The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC.

AB - Many xenobiotics have been associated with endocrine effects in a wide range of biological systems. These associations are usually between small nonsteroid molecules and steroid receptor signaling systems. In this report, triclocarban (TCC; 3,4,4′-trichlorocarbanilide), a common ingredient in personal care products that is used as an antimicrobial agent was evaluated and found to represent a new category of endocrine-disrupting substance. A cell-based androgen receptor-mediated bioassay was used to demonstrate that TCC and other urea compounds with a similar structure, which have little or no endocrine activity when tested alone, act to enhance testosterone (T)-induced androgen receptor-mediated transcriptional activity in vitro. This amplification effect of TCC was also apparent in vivo when 0.25% TCC was added to the diet of castrated male rats that were supported by exogenous testosterone treatment for 10 d. All male sex accessory organs increased significantly in size after the T+TCC treatment, compared with T or TCC treatments alone. The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC.

UR - http://www.scopus.com/inward/record.url?scp=40849139427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40849139427&partnerID=8YFLogxK

U2 - 10.1210/en.2007-1057

DO - 10.1210/en.2007-1057

M3 - Article

VL - 149

SP - 1173

EP - 1179

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 3

ER -