Triazolbenzo[d]thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents

Belem Avila, Aaron Roth, Heather Streets, Donard S. Dwyer, Mark J. Kurth

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.

Original languageEnglish (US)
Pages (from-to)5976-5978
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number18
DOIs
StatePublished - Sep 15 2012

Keywords

  • Click chemistry
  • Neuroprotective agents
  • Triazolbenzo[d]thiazoles

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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