Objective: We sought to determine whether women with ovarian cancer have increased occupational exposure to tnazine herbicides. Methods: A population-based case-control study of incident cases (n = 256) and random digit-dialed control subjects (n = 1122) was conducted. Participants were administered telephone interviews to obtain agricultural work history. These histories were used with the statewide pesticide usage database to calculate cumulative exposure estimates. The data were analyzed by stratified analysis and unconditional logistic regression techniques. Results: The analysis of ever versus never occupational exposure to triazines demonstrated that cases were slightly but not significantly more likely to be exposed than control subjects (adjusted odds = 1.34; 95% confidence interval = 0.77-2.33). There was no evidence of a dose-response relationship between triazines and ovarian cancer (P = 0.22). Conclusions: Considered with previous studies and animal laboratory data, the current evidence is not persuasive as to the presence or absence of an association between ovanan cancer and tnazine exposure.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Occupational and Environmental Medicine|
|State||Published - Nov 2005|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis