Abstract
Objective and Methods: Serum albumin concentrations are associated with mortality, and respond to nutritional and inflammatory states. To explore whether changing demographics and practice patterns in dialysis have influenced serum albumin concentrations, we analyzed trends in serum albumin among incident patients on dialysis from 1995 through 2004. Results: Mean serum albumin concentrations declined significantly over time, even after accounting for changes in age, diabetes, body size, and other factors. Although laboratory assays were not uniform within or across years, serum albumin declined over time, regardless of the reported laboratory lower limit of normal. Moreover, serum albumin retained its potent association with mortality over time. Lower serum albumin was especially hazardous among younger patients and blacks, and was less hazardous among persons with diabetes as a primary cause of kidney disease. Conclusions: Despite higher body weights and the initiation of dialysis earlier in the course of progressive chronic kidney disease, hypoalbuminemia remains common and hazardous to persons starting dialysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 323-331 |
| Number of pages | 9 |
| Journal | Journal of Renal Nutrition |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2008 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Urology
- Food Science
- Nephrology
Cite this
Trends and Outcomes Associated With Serum Albumin Concentration Among Incident Dialysis Patients in the United States. / Kaysen, George; Johansen, Kirsten L.; Cheng, Su Chun; Jin, Chengshi; Chertow, Glenn M.
In: Journal of Renal Nutrition, Vol. 18, No. 4, 07.2008, p. 323-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trends and Outcomes Associated With Serum Albumin Concentration Among Incident Dialysis Patients in the United States
AU - Kaysen, George
AU - Johansen, Kirsten L.
AU - Cheng, Su Chun
AU - Jin, Chengshi
AU - Chertow, Glenn M.
PY - 2008/7
Y1 - 2008/7
N2 - Objective and Methods: Serum albumin concentrations are associated with mortality, and respond to nutritional and inflammatory states. To explore whether changing demographics and practice patterns in dialysis have influenced serum albumin concentrations, we analyzed trends in serum albumin among incident patients on dialysis from 1995 through 2004. Results: Mean serum albumin concentrations declined significantly over time, even after accounting for changes in age, diabetes, body size, and other factors. Although laboratory assays were not uniform within or across years, serum albumin declined over time, regardless of the reported laboratory lower limit of normal. Moreover, serum albumin retained its potent association with mortality over time. Lower serum albumin was especially hazardous among younger patients and blacks, and was less hazardous among persons with diabetes as a primary cause of kidney disease. Conclusions: Despite higher body weights and the initiation of dialysis earlier in the course of progressive chronic kidney disease, hypoalbuminemia remains common and hazardous to persons starting dialysis.
AB - Objective and Methods: Serum albumin concentrations are associated with mortality, and respond to nutritional and inflammatory states. To explore whether changing demographics and practice patterns in dialysis have influenced serum albumin concentrations, we analyzed trends in serum albumin among incident patients on dialysis from 1995 through 2004. Results: Mean serum albumin concentrations declined significantly over time, even after accounting for changes in age, diabetes, body size, and other factors. Although laboratory assays were not uniform within or across years, serum albumin declined over time, regardless of the reported laboratory lower limit of normal. Moreover, serum albumin retained its potent association with mortality over time. Lower serum albumin was especially hazardous among younger patients and blacks, and was less hazardous among persons with diabetes as a primary cause of kidney disease. Conclusions: Despite higher body weights and the initiation of dialysis earlier in the course of progressive chronic kidney disease, hypoalbuminemia remains common and hazardous to persons starting dialysis.
UR - http://www.scopus.com/inward/record.url?scp=44949260196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44949260196&partnerID=8YFLogxK
U2 - 10.1053/j.jrn.2008.04.002
DO - 10.1053/j.jrn.2008.04.002
M3 - Article
C2 - 18558296
AN - SCOPUS:44949260196
VL - 18
SP - 323
EP - 331
JO - Journal of Renal Nutrition
JF - Journal of Renal Nutrition
SN - 1051-2276
IS - 4
ER -