Treatment with botulinum toxin type B for upper-limb spasticity

Allison Brashear, Anita L. McAfee, Elizabeth R. Kuhn, Walter T. Ambrosius

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objective: To determine if botulinum toxin type B (Myo-Bloc) decreases spasticity. Design: Investigator-initiated trial, open-label, single-treatment session. Setting: Single site. Participants: Ten patients with stable upper-limb spasticity and an Ashworth Scale score of 2 or higher at the elbow, wrist, and fingers. Interventions: Total dose of 10, 000U of botulinum toxin type B injected into 5 major muscles. Main Outcome Measures: The Ashworth Scale, goniometry, and functional assessments were performed at injection and weeks 4, 8, and 12. The principal investigator (PI) global assessment of change (GAC) and the patient GAC were done at weeks 4, 8, and 12 postinjection. The safety of the procedure was measured by adverse events and vital signs. Results: Improvements in Ashworth Scale scores were observed at weeks 4, 8, and 12 postinjection. At week 4, the mean changes (in Ashworth score) were elbow, -1.0 (P=.016); wrist, -1.7 (P=.004); finger, -1.35 (P=.02); at week 8: elbow, -.83 (P=.016); wrist, -1.00 (P=.016); finger, -.94 (P=.08); and at week 12: elbow, -.61 (P=.07); wrist, - 1.00 (P=.016); and finger, -.89 (P=.10). The PI GAC improved at all visits. Nine of the 10 subjects reported dry mouth at week 4, with resolution by week 12. No changes were seen on the functional measures. Conclusions: Botulinum toxin type B may be useful in treatment of spasticity.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalArchives of Physical Medicine and Rehabilitation
Issue number1
StatePublished - Jan 2003
Externally publishedYes


  • Botulinum toxins
  • Rehabilitation
  • Spasticity
  • Stroke

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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