Treatment planning for molecular targeted radionuclide therapy

Christine L. Hartmann Siantar, Kai Vetter, Gerald L Denardo, Sally J. DeNardo

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Molecular targeted radionuclide therapy promises to expand the usefulness of radiation to successfully treat widespread cancer. The unique properties of radioactive tags make it possible to plan treatments by predicting the radiation absorbed dose to both tumors and normal organs, using a pre-treatment test dose of radiopharmaceutical. This requires a combination of quantitative, high-resolution, radiation-detection hardware and computerized dose-estimation software, and would ideally include biological dose-response data in order to translate radiation absorbed dose into biological effects. Data derived from conventional (external beam) radiation therapy suggests that accurate assessment of the radiation absorbed dose in dose-limiting normal organs could substantially improve the observed clinical response for current agents used in a myeloablative regimen, enabling higher levels of tumor control at lower tumor-to-normal tissue therapeutic indices. Treatment planning based on current radiation detection and simulations technology is sufficient to impact on clinical response. The incorporation of new imaging methods, combined with patient-specific radiation transport simulations, promises to provide unprecedented levels of resolution and quantitative accuracy, which are likely to increase the impact of treatment planning in targeted radionuclide therapy.

Original languageEnglish (US)
Pages (from-to)267-280
Number of pages14
JournalCancer Biotherapy and Radiopharmaceuticals
Volume17
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Cancer
  • Dosimetry
  • Radiation detection
  • Radionuclide
  • Radiotherapy
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology
  • Cancer Research

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