Treatment planning and volumetric response assessment for yttrium-90 Radioembolization: Semiautomated determination of liver volume and volume of tumor necrosis in patients with hepatic malignancy

Wayne L. Monsky, Armando S. Garza, Isaac Kim, Shaun Loh, Tzu Chun Lin, Chin-Shang Li, Jerron Fisher, Parmbir Sandhu, Vishal Sidhar, Abhijit Chaudhari, Frank Lin, Larry Stuart Deutsch, Ramsey D Badawi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The primary purpose of this study was to demonstrate intraobserver/interobserver reproducibility for novel semiautomated measurements of hepatic volume used for Yttrium-90 dose calculations as well as whole-liver and necrotic-liver (hypodense/nonenhancing) tumor volume after radioembolization. The secondary aim was to provide initial comparisons of tumor volumetric measurements with linear measurements, as defined by Response Evaluation Criteria in Solid Tumors criteria, and survival outcomes. Methods: Between 2006 and 2009, 23 consecutive radioembolization procedures were performed for 14 cases of hepatocellular carcinoma and 9 cases of hepatic metastases. Baseline and follow-up computed tomography obtained 1 month after treatment were retrospectively analyzed. Three observers measured liver, whole-tumor, and tumor-necrosis volumes twice using semiautomated software. Results: Good intraobserver/interobserver reproducibility was demonstrated (intraclass correlation [ICC] > 0.9) for tumor and liver volumes. Semiautomated measurements of liver volumes were statistically similar to those obtained with manual tracing (ICC = 0.868), but they required significantly less time to perform (p < 0.0001, ICC = 0.088). There was a positive association between change in linear tumor measurements and whole-tumor volume (p < 0.0001). However, linear measurements did not correlate with volume of necrosis (p > 0.05). Dose, change in tumor diameters, tumor volume, and necrotic volume did not correlate with survival (p > 0.05 in all instances). However, Kaplan-Meier curves suggest that a >10% increase in necrotic volume correlated with survival (p = 0.0472). Conclusion: Semiautomated volumetric analysis of liver, whole-tumor, and tumor-necrosis volume can be performed with good intraobserver/interobserver reproducibility. In this small retrospective study, measurements of tumor necrosis were suggested to correlate with survival.

Original languageEnglish (US)
Pages (from-to)306-318
Number of pages13
JournalCardioVascular and Interventional Radiology
Volume34
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

Yttrium
Tumor Burden
Necrosis
Liver
Neoplasms
Therapeutics
Survival
Hepatocellular Carcinoma
Software
Retrospective Studies
Tomography
Neoplasm Metastasis

Keywords

  • CT
  • Necrosis
  • Radioembolization
  • Response
  • Tumor
  • Volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Treatment planning and volumetric response assessment for yttrium-90 Radioembolization : Semiautomated determination of liver volume and volume of tumor necrosis in patients with hepatic malignancy. / Monsky, Wayne L.; Garza, Armando S.; Kim, Isaac; Loh, Shaun; Lin, Tzu Chun; Li, Chin-Shang; Fisher, Jerron; Sandhu, Parmbir; Sidhar, Vishal; Chaudhari, Abhijit; Lin, Frank; Deutsch, Larry Stuart; Badawi, Ramsey D.

In: CardioVascular and Interventional Radiology, Vol. 34, No. 2, 04.2011, p. 306-318.

Research output: Contribution to journalArticle

Monsky, Wayne L. ; Garza, Armando S. ; Kim, Isaac ; Loh, Shaun ; Lin, Tzu Chun ; Li, Chin-Shang ; Fisher, Jerron ; Sandhu, Parmbir ; Sidhar, Vishal ; Chaudhari, Abhijit ; Lin, Frank ; Deutsch, Larry Stuart ; Badawi, Ramsey D. / Treatment planning and volumetric response assessment for yttrium-90 Radioembolization : Semiautomated determination of liver volume and volume of tumor necrosis in patients with hepatic malignancy. In: CardioVascular and Interventional Radiology. 2011 ; Vol. 34, No. 2. pp. 306-318.
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abstract = "Purpose: The primary purpose of this study was to demonstrate intraobserver/interobserver reproducibility for novel semiautomated measurements of hepatic volume used for Yttrium-90 dose calculations as well as whole-liver and necrotic-liver (hypodense/nonenhancing) tumor volume after radioembolization. The secondary aim was to provide initial comparisons of tumor volumetric measurements with linear measurements, as defined by Response Evaluation Criteria in Solid Tumors criteria, and survival outcomes. Methods: Between 2006 and 2009, 23 consecutive radioembolization procedures were performed for 14 cases of hepatocellular carcinoma and 9 cases of hepatic metastases. Baseline and follow-up computed tomography obtained 1 month after treatment were retrospectively analyzed. Three observers measured liver, whole-tumor, and tumor-necrosis volumes twice using semiautomated software. Results: Good intraobserver/interobserver reproducibility was demonstrated (intraclass correlation [ICC] > 0.9) for tumor and liver volumes. Semiautomated measurements of liver volumes were statistically similar to those obtained with manual tracing (ICC = 0.868), but they required significantly less time to perform (p < 0.0001, ICC = 0.088). There was a positive association between change in linear tumor measurements and whole-tumor volume (p < 0.0001). However, linear measurements did not correlate with volume of necrosis (p > 0.05). Dose, change in tumor diameters, tumor volume, and necrotic volume did not correlate with survival (p > 0.05 in all instances). However, Kaplan-Meier curves suggest that a >10{\%} increase in necrotic volume correlated with survival (p = 0.0472). Conclusion: Semiautomated volumetric analysis of liver, whole-tumor, and tumor-necrosis volume can be performed with good intraobserver/interobserver reproducibility. In this small retrospective study, measurements of tumor necrosis were suggested to correlate with survival.",
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AU - Garza, Armando S.

AU - Kim, Isaac

AU - Loh, Shaun

AU - Lin, Tzu Chun

AU - Li, Chin-Shang

AU - Fisher, Jerron

AU - Sandhu, Parmbir

AU - Sidhar, Vishal

AU - Chaudhari, Abhijit

AU - Lin, Frank

AU - Deutsch, Larry Stuart

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