Treatment patterns of children with spine and spinal cord tumors: national outcomes and review of the literature

Faris Shweikeh, Carolyn Quinsey, Roger Murayi, Ryan Randle, Miriam A Nuno, Mark D. Krieger, J. Patrick Johnson

Research output: Contribution to journalArticle

Abstract

Background: Tumors of the spine in children are rare, and further clinical description is necessary. Objective: This study investigated epidemiology, interventions, and outcomes of pediatric patients with spine and spinal cord tumors. Methods: The National Inpatient Sample and Kids’ Inpatient Database were used for the study. Outcomes were studied, and bivariate significant trends were analyzed in a multivariate setting. Results: Analysis of 2870 patients between 2000 and 2009 found a median age of diagnosis of 11 years (Tables 1 and 2). Most were white (65.2%) and had private insurance (62.3%), and 46.8% of procedures were emergent operations. Treatment occurred at teaching (93.6%) and non-children’s hospitals (81.1%). Overall mortality rate was 1.7%, non-routine discharges occurred at a rate 19.9%, complications at 21.1%, and average total charges were $66,087. A majority of patients (87.5%) had no intervention, and of those patients receiving treatment, 78.2% underwent surgery and 23.1% had radiotherapy. Treatment with surgery alone increased significantly over time (p < 0.0001). Odds ratio (OR) of mortality was significantly higher in 2006 (OR 3.5) and 2009 (OR 2.6) when compared to 2000. Complications (OR 7.9) and disease comorbidities (OR 1.5) were associated with significantly increased odds of mortality. Conclusions: Hospital characteristics, length of stay, and charges remained relatively unchanged. In recent years, there has been a decreasing incidence of spine and spinal cord tumors in children. Notably, a higher mortality rate is evident over time in addition to an increase in the proportion of patients undergoing surgery. The high percentage of emergent operations suggests a weak recognition of spine tumors in children and should prompt a call for increased awareness of this cancer. In spite of these findings, lack of tumor type identification was a limitation to this study.

Original languageEnglish (US)
Pages (from-to)1357-1365
Number of pages9
JournalChild's Nervous System
Volume33
Issue number8
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Fingerprint

Spinal Cord Neoplasms
Spine
Odds Ratio
Mortality
Inpatients
Neoplasms
Therapeutics
Insurance
Comorbidity
Length of Stay
Teaching
Epidemiology
Radiotherapy
Databases
Pediatrics
Incidence

Keywords

  • Children
  • Healthcare costs
  • Oncology
  • Pediatric spine
  • Radiation
  • Spinal cord tumors
  • Spine surgery
  • Survival

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Treatment patterns of children with spine and spinal cord tumors : national outcomes and review of the literature. / Shweikeh, Faris; Quinsey, Carolyn; Murayi, Roger; Randle, Ryan; Nuno, Miriam A; Krieger, Mark D.; Patrick Johnson, J.

In: Child's Nervous System, Vol. 33, No. 8, 01.08.2017, p. 1357-1365.

Research output: Contribution to journalArticle

Shweikeh, Faris ; Quinsey, Carolyn ; Murayi, Roger ; Randle, Ryan ; Nuno, Miriam A ; Krieger, Mark D. ; Patrick Johnson, J. / Treatment patterns of children with spine and spinal cord tumors : national outcomes and review of the literature. In: Child's Nervous System. 2017 ; Vol. 33, No. 8. pp. 1357-1365.
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abstract = "Background: Tumors of the spine in children are rare, and further clinical description is necessary. Objective: This study investigated epidemiology, interventions, and outcomes of pediatric patients with spine and spinal cord tumors. Methods: The National Inpatient Sample and Kids’ Inpatient Database were used for the study. Outcomes were studied, and bivariate significant trends were analyzed in a multivariate setting. Results: Analysis of 2870 patients between 2000 and 2009 found a median age of diagnosis of 11 years (Tables 1 and 2). Most were white (65.2{\%}) and had private insurance (62.3{\%}), and 46.8{\%} of procedures were emergent operations. Treatment occurred at teaching (93.6{\%}) and non-children’s hospitals (81.1{\%}). Overall mortality rate was 1.7{\%}, non-routine discharges occurred at a rate 19.9{\%}, complications at 21.1{\%}, and average total charges were $66,087. A majority of patients (87.5{\%}) had no intervention, and of those patients receiving treatment, 78.2{\%} underwent surgery and 23.1{\%} had radiotherapy. Treatment with surgery alone increased significantly over time (p < 0.0001). Odds ratio (OR) of mortality was significantly higher in 2006 (OR 3.5) and 2009 (OR 2.6) when compared to 2000. Complications (OR 7.9) and disease comorbidities (OR 1.5) were associated with significantly increased odds of mortality. Conclusions: Hospital characteristics, length of stay, and charges remained relatively unchanged. In recent years, there has been a decreasing incidence of spine and spinal cord tumors in children. Notably, a higher mortality rate is evident over time in addition to an increase in the proportion of patients undergoing surgery. The high percentage of emergent operations suggests a weak recognition of spine tumors in children and should prompt a call for increased awareness of this cancer. In spite of these findings, lack of tumor type identification was a limitation to this study.",
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AU - Krieger, Mark D.

AU - Patrick Johnson, J.

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KW - Radiation

KW - Spinal cord tumors

KW - Spine surgery

KW - Survival

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