Treatment options for posttraumatic epilepsy

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Purpose of review Posttraumatic seizures (PTS) and posttraumatic epilepsy (PTE) are common and debilitating consequences of traumatic brain injury (TBI). Early PTS result in secondary brain injury by raising intracranial pressure and worsening cerebral edema and metabolic crisis. PTE is a localization-related epilepsy strongly associated with TBI severity, but risk factors for PTE and epileptogenesis are incompletely understood and are active areas of research. Medical management of PTS in adults and children is reviewed. Surgical options for posttraumatic drug-resistant epilepsy are also discussed. Recent findings Continuous electroencephalography is indicated for children and adults with TBI and coma because of the high incidence of nonconvulsive seizures, periodic discharges, and associated secondary brain injury in this population. Neuroinflammation is a central component of secondary brain injury and appears to play a key role in epileptogenesis. Levetiracetam is increasingly used for seizure prophylaxis in adults and children, but variability remains. Summary PTS occur commonly after TBI and are associated with secondary brain injury and worse outcomes in adults and children. Current medical and surgical management options for PTS and PTE are reviewed.

Original languageEnglish (US)
Pages (from-to)580-586
Number of pages7
JournalCurrent Opinion in Neurology
Volume30
Issue number6
DOIs
StatePublished - Dec 1 2017

Fingerprint

Epilepsy
Seizures
Brain Injuries
etiracetam
Therapeutics
Partial Epilepsy
Brain Edema
Intracranial Pressure
Coma
Electroencephalography
Traumatic Brain Injury
Incidence
Research
Population

Keywords

  • continuous electroencephalography
  • ictal-interictal continuum
  • metabolic crisis
  • nonconvulsive seizure
  • traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Treatment options for posttraumatic epilepsy. / Zimmermann, Lara; Martin, Ryan; Girgis, Fady.

In: Current Opinion in Neurology, Vol. 30, No. 6, 01.12.2017, p. 580-586.

Research output: Contribution to journalReview article

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