Treatment options for hypertriglyceridemia: From risk reduction to pancreatitis

Lars Berglund, John D. Brunzell, Anne C. Goldberg, Ira J. Goldberg, Anton Stalenhoef

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

While there has been considerable focus on the role and treatment of LDL cholesterol levels, a definitive role of triglycerides in the management of cardiovascular disease has been uncertain. Notably, with increasing triglyceride levels, there is a parallel increase in cholesterol levels carried by triglyceride-rich lipoproteins, which has prompted interest in the use of non-HDL cholesterol levels as a tool guiding interventions. Recent studies have provided evidence for an independent role of triglyceride levels as a cardiovascular risk factor, and recently, an Endocrine Society guideline was published for treatment of hypertriglyceridemia. In contrast to the relative uncertainty regarding triglycerides and cardiovascular disease, a role of very high triglyceride levels as a risk factor for pancreatitis has been well known. The present paper summarizes the underlying evidence for a risk role for triglyceride levels in cardiovascular disease and pancreatitis, current treatment recommendations and areas of future research.

Original languageEnglish (US)
Pages (from-to)423-437
Number of pages15
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume28
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Hypertriglyceridemia
Risk Reduction Behavior
Pancreatitis
Triglycerides
Cardiovascular Diseases
Cholesterol
LDL Cholesterol
Lipoproteins
Uncertainty
Guidelines

Keywords

  • coronary heart disease
  • dyslipidemia
  • hypolipidemic therapy
  • lifestyle intervention
  • lipoproteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Treatment options for hypertriglyceridemia : From risk reduction to pancreatitis. / Berglund, Lars; Brunzell, John D.; Goldberg, Anne C.; Goldberg, Ira J.; Stalenhoef, Anton.

In: Best Practice and Research: Clinical Endocrinology and Metabolism, Vol. 28, No. 3, 2014, p. 423-437.

Research output: Contribution to journalArticle

Berglund, Lars ; Brunzell, John D. ; Goldberg, Anne C. ; Goldberg, Ira J. ; Stalenhoef, Anton. / Treatment options for hypertriglyceridemia : From risk reduction to pancreatitis. In: Best Practice and Research: Clinical Endocrinology and Metabolism. 2014 ; Vol. 28, No. 3. pp. 423-437.
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