Treatment of refractory large granular lymphocytic leukemia with 2-chlorodeoxyadenosine

Martin J. Edelman, Robert T O'Donnell, Ivan Meadows

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A 50-year-old man with large granular lymphocytic leukemia (CD3+, CD8+) complicated by severe pancytopenia and life-threatening infections refractory to therapy with prednisone, methotrexate, cyclosporine, and G-CSF is described. Treatment with two cycles of 2-chlorodeoxyadenosine (2-CDA) at 0.1 mg/kg by continuous intravenous infusion for 7 days each cycle resulted in resolution of cytopenias and clearance of leukemic cells. T-cell receptor gene rearrangement, initially present, was not detectable after therapy with 2-CDA. The rapid and complete response to 2-CDA after unsuccessful attempts with prior therapy suggests that 2-CDA should be considered for initial treatment of this disorder.

Original languageEnglish (US)
Pages (from-to)329-331
Number of pages3
JournalAmerican Journal of Hematology
Volume54
Issue number4
DOIs
StatePublished - Apr 1997

Keywords

  • 2-Chlorodeoxyadenosine
  • Large granular lymphocytic leukemia

ASJC Scopus subject areas

  • Hematology

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