Treatment of refractory large granular lymphocytic leukemia with 2-chlorodeoxyadenosine

Martin J. Edelman, Robert T O'Donnell, Ivan Meadows

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 50-year-old man with large granular lymphocytic leukemia (CD3+, CD8+) complicated by severe pancytopenia and life-threatening infections refractory to therapy with prednisone, methotrexate, cyclosporine, and G-CSF is described. Treatment with two cycles of 2-chlorodeoxyadenosine (2-CDA) at 0.1 mg/kg by continuous intravenous infusion for 7 days each cycle resulted in resolution of cytopenias and clearance of leukemic cells. T-cell receptor gene rearrangement, initially present, was not detectable after therapy with 2-CDA. The rapid and complete response to 2-CDA after unsuccessful attempts with prior therapy suggests that 2-CDA should be considered for initial treatment of this disorder.

Original languageEnglish (US)
Pages (from-to)329-331
Number of pages3
JournalAmerican Journal of Hematology
Volume54
Issue number4
DOIs
StatePublished - Apr 1997

Fingerprint

Large Granular Lymphocytic Leukemia
Cladribine
T-Lymphocyte Gene Rearrangement
Therapeutics
T-Cell Receptor Genes
Pancytopenia
Granulocyte Colony-Stimulating Factor
Prednisone
Intravenous Infusions
Methotrexate
Infection

Keywords

  • 2-Chlorodeoxyadenosine
  • Large granular lymphocytic leukemia

ASJC Scopus subject areas

  • Hematology

Cite this

Treatment of refractory large granular lymphocytic leukemia with 2-chlorodeoxyadenosine. / Edelman, Martin J.; O'Donnell, Robert T; Meadows, Ivan.

In: American Journal of Hematology, Vol. 54, No. 4, 04.1997, p. 329-331.

Research output: Contribution to journalArticle

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