Treatment of proximal deep-vein thrombosis using subcutaneously administered calcium heparin: Comparison with intravenous sodium heparin

Richard H White, M. M. Daschbach, John P McGahan, K. Keck, G. H. Parsons, R. P. Hartling, D. Mungall

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In a prospective, randomized clinical trial we compared the efficacy of subcutaneously (SC) administered (every 8 h) calcium heparin to intravenous (IV) sodium heparin in the treatment of proximal deep-vein thrombosis (DVT). A secondary objective was to give enough heparin to achieve a therapeutic anticoagulant effect by the end of the first 24 h. Five of 36 patients (14%) in the SC heparin group failed to achieve a therapeutic anticoagulant effect by the end of the first 24 h compared to 2 of 23 patients (9%) in the IV group (p = NS; 95% CI for true difference = -11.7% to 22.1%). Two of 31 patients (6.5%) in the SC group had venographic evidence of clot propagation compared to 1 of 19 patients (5.3%) in the IV group (p = NS; 95% CI for true difference = -12.4% to 14.8%). The rate of major hemorrhagic complications was similar in each group (~ 15%). We conclude: (1) using a large initial dose of SC heparin, a therapeutic anticoagulant effect can be readily achieved within 24 h, and (2) combining the results of this trial with previous studies, the efficacy of SC administered calcium appears to be comparable to IV sodium heparin.

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalHaemostasis
Volume22
Issue number3
StatePublished - 1992

Keywords

  • anticoagulation
  • heparin
  • thrombophlebitis
  • venous thrombosis

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Treatment of proximal deep-vein thrombosis using subcutaneously administered calcium heparin: Comparison with intravenous sodium heparin'. Together they form a unique fingerprint.

  • Cite this