Treatment of myeloid blastic crisis of chronic myelogenous leukemia

H. D. Preisler, A. Raza, D. Higby, J. Kirshner, J. Woll, J. Bennett, L. Winton, R. Weiner, Carol M Richman, H. Golomb

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Patients with myeloid blastic crisis of chronic myelogenous leukemia were treated by chemotherapy or by autologous hematopoietic reconstitution after aggressive chemotherapy. Chemotherapy alone failed to produce a second chronic phase. Autologous transplantation resulted in the establishment of a second chronic phase in two of ten patients treated with a four-drug regimen, while treatment with high-dose cytarabine with or without busulfan resulted in the establishment of a second chronic phase in three of six patients and the return of normal hematopoiesis in a fourth. Consolidation chemotherapy appeared to be beneficial.

Original languageEnglish (US)
Pages (from-to)1351-1355
Number of pages5
JournalCancer Treatment Reports
Volume68
Issue number11
StatePublished - 1984
Externally publishedYes

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Drug Therapy
Consolidation Chemotherapy
Busulfan
Autologous Transplantation
Cytarabine
Hematopoiesis
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Preisler, H. D., Raza, A., Higby, D., Kirshner, J., Woll, J., Bennett, J., ... Golomb, H. (1984). Treatment of myeloid blastic crisis of chronic myelogenous leukemia. Cancer Treatment Reports, 68(11), 1351-1355.

Treatment of myeloid blastic crisis of chronic myelogenous leukemia. / Preisler, H. D.; Raza, A.; Higby, D.; Kirshner, J.; Woll, J.; Bennett, J.; Winton, L.; Weiner, R.; Richman, Carol M; Golomb, H.

In: Cancer Treatment Reports, Vol. 68, No. 11, 1984, p. 1351-1355.

Research output: Contribution to journalArticle

Preisler, HD, Raza, A, Higby, D, Kirshner, J, Woll, J, Bennett, J, Winton, L, Weiner, R, Richman, CM & Golomb, H 1984, 'Treatment of myeloid blastic crisis of chronic myelogenous leukemia', Cancer Treatment Reports, vol. 68, no. 11, pp. 1351-1355.
Preisler HD, Raza A, Higby D, Kirshner J, Woll J, Bennett J et al. Treatment of myeloid blastic crisis of chronic myelogenous leukemia. Cancer Treatment Reports. 1984;68(11):1351-1355.
Preisler, H. D. ; Raza, A. ; Higby, D. ; Kirshner, J. ; Woll, J. ; Bennett, J. ; Winton, L. ; Weiner, R. ; Richman, Carol M ; Golomb, H. / Treatment of myeloid blastic crisis of chronic myelogenous leukemia. In: Cancer Treatment Reports. 1984 ; Vol. 68, No. 11. pp. 1351-1355.
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