Abstract
Patients with myeloid blastic crisis of chronic myelogenous leukemia were treated by chemotherapy or by autologous hematopoietic reconstitution after aggressive chemotherapy. Chemotherapy alone failed to produce a second chronic phase. Autologous transplantation resulted in the establishment of a second chronic phase in two of ten patients treated with a four-drug regimen, while treatment with high-dose cytarabine with or without busulfan resulted in the establishment of a second chronic phase in three of six patients and the return of normal hematopoiesis in a fourth. Consolidation chemotherapy appeared to be beneficial.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1351-1355 |
| Number of pages | 5 |
| Journal | Cancer Treatment Reports |
| Volume | 68 |
| Issue number | 11 |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Treatment of myeloid blastic crisis of chronic myelogenous leukemia. / Preisler, H. D.; Raza, A.; Higby, D.; Kirshner, J.; Woll, J.; Bennett, J.; Winton, L.; Weiner, R.; Richman, Carol M; Golomb, H.
In: Cancer Treatment Reports, Vol. 68, No. 11, 1984, p. 1351-1355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of myeloid blastic crisis of chronic myelogenous leukemia
AU - Preisler, H. D.
AU - Raza, A.
AU - Higby, D.
AU - Kirshner, J.
AU - Woll, J.
AU - Bennett, J.
AU - Winton, L.
AU - Weiner, R.
AU - Richman, Carol M
AU - Golomb, H.
PY - 1984
Y1 - 1984
N2 - Patients with myeloid blastic crisis of chronic myelogenous leukemia were treated by chemotherapy or by autologous hematopoietic reconstitution after aggressive chemotherapy. Chemotherapy alone failed to produce a second chronic phase. Autologous transplantation resulted in the establishment of a second chronic phase in two of ten patients treated with a four-drug regimen, while treatment with high-dose cytarabine with or without busulfan resulted in the establishment of a second chronic phase in three of six patients and the return of normal hematopoiesis in a fourth. Consolidation chemotherapy appeared to be beneficial.
AB - Patients with myeloid blastic crisis of chronic myelogenous leukemia were treated by chemotherapy or by autologous hematopoietic reconstitution after aggressive chemotherapy. Chemotherapy alone failed to produce a second chronic phase. Autologous transplantation resulted in the establishment of a second chronic phase in two of ten patients treated with a four-drug regimen, while treatment with high-dose cytarabine with or without busulfan resulted in the establishment of a second chronic phase in three of six patients and the return of normal hematopoiesis in a fourth. Consolidation chemotherapy appeared to be beneficial.
UR - http://www.scopus.com/inward/record.url?scp=0021738684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021738684&partnerID=8YFLogxK
M3 - Article
C2 - 6388833
AN - SCOPUS:0021738684
VL - 68
SP - 1351
EP - 1355
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 11
ER -